...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research >Assessment of deoxynivalenol exposure among Bangladeshi and German adults by a biomarker-based approach
【24h】

Assessment of deoxynivalenol exposure among Bangladeshi and German adults by a biomarker-based approach

机译：基于生物标志物的方法评估孟加拉国和德国成年人中的脱氧酚暴露

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Deoxynivalenol (DON) is a frequent mycotoxin contaminant in cereal crops worldwide and can cause adverse health effects in exposed animals and humans. Since DON contamination in Bangladeshi food is unexplored, we conducted a biomonitoring study to assess DON exposure in the Bangladeshi population and compare it with that of German adults. In total 214 urines were collected, n = 164 in Bangladesh and n = 50 in Germany. In Bangladesh rural and urban residents of Rajshahi district provided urines in two seasons (n = 69 in summer, n = 95 in winter, with 62 participants enrolled in both periods). Urinary DON and its de-epoxy metabolite DOM-1 were measured by a previously validated sensitive LC-MS/MS method. In Bangladeshi urines, DON was detectable in 27% (range 0.16-1.78 ng/mL) in summer and 31% (range 0.16-1.21 ng/mL) in winter season. There was no significant difference at the mean DON level between season (summer 0.17 +/- 0.25 ng/mL and winter 0.16 +/- 0.18 ng/mL) and region (rural or urban residents). The metabolite DOM-1 was not detected in any urine from Bangladesh. In contrast, DON and DOM-1 were detected in 100% (range 0.16-38.44 ng/mL) and 40% (range 0.10-0.73 ng/mL), respectively, of the German urines. The mean DON level in German urines (9.02 +/- 6.84 ng/mL) was about 53-fold higher than that found in Bangladeshi samples. This indicates a low and high dietary DON exposure among the adult population in Bangladesh and Germany, respectively. The biomarker concentrations found and published urinary excretion rates for DON then served to calculate the daily mycotoxin intake in both cohorts: the mean DON intake in Bangladesh being 6 ng/kg b.w., and in Germany a mean of 268 and maximum intake of 975 ng/kg b.w., values lower than the provisional maximum tolerable daily intake of 1 mg/kg b.w. set by the WHO/JECFA. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
机译：脱氧性苯酚（Don）是全世界谷物作物的常见霉菌毒素污染物，可引起暴露的动物和人类的不良健康影响。由于孟加拉国食物的唐污染是未开发的，我们进行了一种生物监测研究，以评估孟加拉国人口的唐暴露，并将其与德国成年人进行比较。总收集了214例尿道，孟加拉国的n = 164，德国N = 50。在孟加拉国农村和城市居民的拉贾山地区提供了两个季节的尿道（夏季N = 69，冬季N = 95，两个期间参加了62名参与者）。通过先前验证的敏感LC-MS / MS方法测量尿道和其去环氧代谢物DOM-1。在孟加拉国尿中，冬季，Don在夏季可检测为27％（范围为0.16-1.78毫升/ ml），冬季31％（范围为0.16-1.21毫克/ ml）。季节之间的平均唐水平没有显着差异（夏季0.17 +/- 0.25 ng / ml和冬季0.16 +/- 0.18 ng / ml）和区域（农村或城市居民）。在孟加拉国的任何尿液中未检测到代谢物DOM-1。相比之下，德国尿素分别以100％（范围为0.16-38.44ng / ml）和40％（范围0.10-0.73ng / ml）的40％（范围为0.10-0.73ng / ml）的DON和DOM-1。德国尿的平均唐水平（9.02 +/- 6.84 ng / ml）比孟加拉国样品更高约53倍。这表明孟加拉国和德国的成年人口中的低膳食唐暴露。发现生物标志物浓度和发表的尿液排泄率为DON的尿液排泄率，以计算群组中的每日霉菌毒素摄入量：孟加拉国的平均唐摄入量为6 ng / kg BW，德国均为268的平均值，最高摄入975 ng / kg bw，低于临时最大可容忍每日摄入1 mg / kg bw的值由谁/ jecfa设置。 （c）2016 Elsevier Ireland Ltd.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号