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首页> 外文期刊>Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research >A pharmacokinetic analysis and dietary information are necessary to confirm or reject the hypothesis on persistent organic pollutants causing type 2 diabetes
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A pharmacokinetic analysis and dietary information are necessary to confirm or reject the hypothesis on persistent organic pollutants causing type 2 diabetes

机译：药代动力学分析和膳食信息是确认或拒绝持续有机污染物的假设，导致2型糖尿病

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A number of studies have found an association between the concentrations of persistent organic pollutants (POP) and type 2 diabetes. Causality has remained uncertain. This study describes the pharmacokinetic behavior of PCDD/Fs (polychlorinated dibenzo-p-dioxins and dibenzofurans) both in a theoretical model based on elimination rate constants, and in a group of 409 adult surgical patients with known PCDD/F concentrations and dietary information. A model assuming 10% annual decrease in past PCDD/F intake, predicted the measured profile of TEQ (toxic equivalents) in the patient population fairly well. The dominant determinant of PCDD/F level was age, and the level in patients was also associated with consumption of animal source products. Predicted daily intakes correlated with diet, but also with body mass index (BMI), indicating that high BMI was preceded by high consumption of foods containing PCDD/Fs. The results suggest that a third factor, e. g. high intake of animal source foods, could explain both higher levels of POPs in the body and higher incidence of type 2 diabetes, and BMI is not sufficient in describing the confounding caused by diet. Thus, to fully address the causality between POPs and type 2 diabetes, careful studies considering the pharmacokinetics of the studied compounds, and including the analysis of food consumption, are needed. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
机译：许多研究发现持续有机污染物（POP）和2型糖尿病浓度之间的关联。因果关系仍然不确定。本研究描述了PCDD / FS（多氯二苯并二恶蛋白和二苯并呋喃）的药代动力学行为在基于消除速率常数的理论模型中，并在一组409名成人手术患者中，具有已知的PCDD / F浓度和膳食信息。假设过去PCDD / F摄入量10％减少的模型，预测了患者人口中的TEQ（有毒等同物）的测量型材相当良好。 PCDD / F水平的主要决定因素是年龄，患者的水平也与动物源产品的消费有关。预测的每日摄入量与饮食相关，也与体重指数（BMI）相关，表明高BMI在含有PCDD / FS的高消耗之前。结果表明第三个因素，即G。高摄入动物源食物，可以解释身体的含量较高，2型糖尿病的发病率较高，BMI不足以描述由饮食引起的混杂。因此，为了充分解决POPS和2型糖尿病之间的因果关系，需要考虑研究的化合物的药代动力学，并且包括分析食品消费的仔细研究。 （c）2016 Elsevier Ireland Ltd.保留所有权利。

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