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首页> 外文期刊>Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research >Grape seed extract ameliorates bleomycin-induced mouse pulmonary fibrosis
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Grape seed extract ameliorates bleomycin-induced mouse pulmonary fibrosis

机译：葡萄籽提取物改善博莱霉素诱导的小鼠肺纤维化

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摘要

Pulmonary fibrosis is common in a variety of inflammatory lung diseases, such as interstitial pneumonia, chronic obstructive pulmonary disease, and silicosis. There is currently no effective clinical drug treatment. It has been reported that grape seed extracts (GSE) has extensive pharmacological effects with minimal toxicity. Although it has been found that GSE can improve the lung collagen deposition and fibrosis pathology induced by bleomycin in rat, its effects on pulmonary function, inflammation, growth factors, matrix metalloproteinases and epithelial-mesenchymal transition remain to be researched. In the present study, we studied whether GSE provided protection against bleomycin (BLM)-induced mouse pulmonary fibrosis. ICR strain mice were treated with BLM in order to establish pulmonary fibrosis models. GSE was given daily via intragastric administration for three weeks starting at one day after intratracheal instillation. GSE at 50 or 100 mg/kg significantly reduced BLM-induced inflammatory cells infiltration, proinflammatory factor protein expression, and hydroxyproline in lung tissues, and improved pulmonary function in mice. Additionally, treatment with GSE also significantly impaired BLM-induced increases in lung fibrotic marker expression (collagen type I alpha 1 and fibronectin 1) and decreases in an anti- fibrotic marker (E-cadherin). Further investigation indicated that the possible molecular targets of GSE are matrix metalloproteinases-9 (MMP-9) and TGF-beta 1, given that treatment with GSE significantly prevented BLM-induced increases in MMP-9 and TGF-beta 1 expression in the lungs. Together, these results suggest that supplementation with GSE may improve the quality of life of lung fibrosis patients by inhibiting MMP-9 and TGF-beta 1 expression in the lungs. (C) 2017 Elsevier B.V. All rights reserved.
机译：肺纤维化在各种炎症肺病中是常见的，例如间质性肺炎，慢性阻塞性肺病和矽肺病。目前没有有效的临床药物治疗。据报道，葡萄种子提取物（GSE）具有广泛的药理学作用，毒性最小。虽然已经发现GSE可以改善通过大鼠的Bleomycin诱导的肺胶原沉积和纤维化病理，但其对肺功能，炎症，生长因子，基质金属蛋白酶和上皮 - 间充质转换的影响仍然研究。在本研究中，我们研究了GSE是否为博来霉素（BLM）引起的小鼠肺纤维化提供了保护。用BLM处理ICR应变小鼠，以建立肺纤维化模型。 GSE每天通过胃内给药给每天三周开始，在肿瘤内滴注后一天开始。 GSE在50或100mg / kg中显着降低了BLM诱导的炎症细胞浸润，促炎因子蛋白表达和肺组织中的羟脯氨酸，以及改善小鼠的肺功能。另外，使用GSE的治疗也显着受损BLM诱导的肺纤维化标记表达（胶原I alpha 1和纤连蛋白1）的增加，并降低抗纤维化标记物（E-Cadherin）。进一步的研究表明，鉴于使用GSE的治疗显着防止肺部的MMP-9和TGF-β1表达，GSE的可能分子靶标是基质金属蛋白酶-9（MMP-9）和TGF-BETA 1。 。这些结果表明，通过抑制肺中的MMP-9和TGF-β1表达，GSE的补充可以提高肺纤维化患者的生活质量。 （c）2017 Elsevier B.v.保留所有权利。

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