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首页> 外文期刊>AIDS Research and Human Retroviruses >Associations of Circulating Soluble Tumor Necrosis Factor-alpha Receptors 1 and 2 with Interleukin-6 Levels in an Aging Cohort of Injection Drug Users with or at High Risk for HIV Infection
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Associations of Circulating Soluble Tumor Necrosis Factor-alpha Receptors 1 and 2 with Interleukin-6 Levels in an Aging Cohort of Injection Drug Users with or at High Risk for HIV Infection

机译：在有或具有高感染HIV风险的老龄化注射吸毒人群中，循环可溶性肿瘤坏死因子-α受体1和2与白细胞介素6水平的关联

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Chronic inflammation marked by elevated interleukin (IL)-6, soluble tumor necrosis factor (TNF)- receptor (sTNFR)-1, and sTNFR-2 levels may play a detrimental role in aging and HIV infection. This study aimed to evaluate the relationships of circulating IL-6 with sTNFR-1 and sTNFR-2 levels in an aging cohort of injection drug users (IDUs) with or at high risk for HIV infection. The AIDS Linked to the Intravenous Experience (ALIVE) study is a community-recruited, prospective observational study of former and current IDUs in Baltimore, Maryland. Serum IL-6, sTNFR-1, and sTNFR-2 levels were measured using standard ELISA. Multivariate linear regression analysis was employed, adjusting for age, sex, HIV status, injection drug use, comorbidities, as well as HIV viral load, CD4 T cell counts, and antiretroviral therapy where appropriate. The analysis included 1,178 participants (316 HIV positive and 862 HIV negative). In the adjusted model, sTNFR-1 and sTNFR-2 were individually associated with IL-6 (regression coefficient: 0.877 and 0.556, respectively, for all participants; 0.607 and 0.407 for HIV positives; and 0.999 and 0.628 for HIV negatives, all p<0.0001). In the model combining sTNFR-1 and sTNFR-2, the associations for sTNFR-1 remained significant (0.693 for all participants, p<0.0001; 0.417 for HIV positives, p<0.05; and 0.840 for HIV negatives), while those for sTNFR-2 were no longer significant. sTNFR-1 and sTNFR-2 were positively associated with IL-6 in ALIVE participants. These findings provide initial insight into the in vivo relationship between TNF- activation and IL-6 and a basis for further investigations into potential mechanisms underlying chronic inflammation in aging and HIV infection.
机译：以白介素（IL）-6，可溶性肿瘤坏死因子（TNF）-受体（sTNFR）-1和sTNFR-2水平升高为特征的慢性炎症可能在衰老和HIV感染中起有害作用。这项研究的目的是评估在有艾滋病毒感染风险或处于艾滋病毒高风险的注射吸毒者（IDU）老龄化人群中循环IL-6与sTNFR-1和sTNFR-2水平的关系。艾滋病与静脉注射相关研究（ALIVE）是一项针对马里兰州巴尔的摩市以前和现在的注射毒品使用者的社区招募性前瞻性观察性研究。使用标准ELISA测量血清IL-6，sTNFR-1和sTNFR-2水平。采用多变量线性回归分析，调整年龄，性别，HIV状况，注射药物使用，合并症，HIV病毒载量，CD4 T细胞计数和适当的抗逆转录病毒疗法。该分析包括1,178名参与者（316例HIV阳性和862例HIV阴性）。在调整后的模型中，sTNFR-1和sTNFR-2分别与IL-6相关（所有参与者的回归系数分别为0.877和0.556; HIV阳性者的回归系数分别为0.607和0.407; HIV阴性者的回归系数分别为0.999和0.628。 <0.0001）。在结合sTNFR-1和sTNFR-2的模型中，sTNFR-1的关联仍然很显着（所有参与者为0.693，p <0.0001; HIV阳性为0.417，p <0.05; HIV阴性为0.840），而sTNFR的相关性-2不再重要。 sTNFR-1和sTNFR-2与ALIVE参与者的IL-6正相关。这些发现为TNF激活与IL-6的体内关系提供了初步的见识，并为进一步研究衰老和HIV感染中慢性炎症的潜在机制奠定了基础。

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