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首页> 外文期刊>AIDS Research and Human Retroviruses >Physical Activity and Its Association with Insulin Resistance in Multicenter AIDS Cohort Study Men
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Physical Activity and Its Association with Insulin Resistance in Multicenter AIDS Cohort Study Men

机译：多中心艾滋病队列研究人群的体育锻炼及其与胰岛素抵抗的关系

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The association between physical activity (PA), degree of insulin resistance (IR), and HIV infection is unclear. We hypothesized that PA might differentially affect the degree of IR through the direct and indirect influences of HIV, antiretroviral medications, and sociodemographic characteristics. The International Physical Activity Questionnaire (IPAQ) was administered to Multicenter AIDS Cohort Study (MACS) participants from 4/2010 to 3/2011 to generate metabolic equivalents (METs) total score and PA category. We determined the concurrent homeostatic model assessment IR (mmol/liter) (HOMA-IR) value from fasting glucose and insulin. We examined the HIV-PA relationship using quantile regression and the HIV-PA-HOMA-IR value relationship using linear regression. Among the 1,281 men, the proportions of men in the low (25% in HIV+ vs. 23% in HIV-), moderate (26% vs. 27%), and high (49% vs. 49%) PA categories were similar by HIV status. The HOMA-IR value was higher among the HIV+ men (p<0.001), and both HIV infection and low PA were associated with a higher degree of IR (p<0.0001 and p=0.0007). However, the PA-HOMA-IR value interaction was not different by HIV status. The HOMA-IR value was higher among HIV+ men although the PA was similar. It is unknown if more exercise will overcome the metabolic derangements associated with HIV and its treatment.
机译：身体活动（PA），胰岛素抵抗（IR）程度和HIV感染之间的关联尚不清楚。我们假设PA可能通过HIV，抗逆转录病毒药物和社会人口学特征的直接和间接影响而不同地影响IR的程度。从4/2010至3/2011对多中心艾滋病队列研究（MACS）参与者进行了国际体育活动问卷（IPAQ），以产生代谢当量（METs）总分和PA类别。我们根据空腹血糖和胰岛素确定了同时进行的稳态模型评估IR（毫摩尔/升）（HOMA-IR）值。我们使用分位数回归检查了HIV-PA关系，使用线性回归检查了HIV-PA-HOMA-IR值关系。在1,281名男性中，低（PA +）类别（25％相对于HIV-）的23％，中度（26％与27％）和高（49％与49％）PA类别的男性比例相似根据艾滋病毒状况。在HIV +男性中，HOMA-IR值较高（p <0.001），并且HIV感染和低PA均与较高的IR程度相关（p <0.0001和p = 0.0007）。但是，PA-HOMA-IR值的交互作用在HIV状况方面没有差异。尽管PA相似，但HIV +男性的HOMA-IR值较高。尚不清楚是否更多的运动能克服与HIV及其治疗有关的代谢紊乱。

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