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首页> 外文期刊>AIDS Research and Human Retroviruses >Short Communication: Low False Recent Rate of Limiting-Antigen Avidity Assay Among Long-Term Infected Subjects from Guangxi, China
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Short Communication: Low False Recent Rate of Limiting-Antigen Avidity Assay Among Long-Term Infected Subjects from Guangxi, China

机译：简短的交流：来自中国广西的长期感染患者中限制抗原亲和力测定的近期错误率低

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摘要

Assays used for HIV cross-sectional incidence testing can misclassify some individuals with nonrecent HIV infection as recently infected, overestimating HIV incidence. We analyzed the frequency and factors associated with false-recent misclassification on subjects from Quangxi, China known to have long-term infection using the limited antigen-avidity assay (LAg-Avidity). Stored samples from treatment-naive individuals from Guangxi, China were tested using the LAg-Avidity. A total of 362 samples from individuals known to be infected 2 to 13.5 years were tested and the false-recent rate (FRR), the frequency of samples with a positive result, was determined at different cutoff values of the assay. Additionally, factors associated with misclassification were determined. The FRR of the LAg-Avidity was 1.1% (4/362) using a cutoff of 1.5 normalized optical density units (OD-n). All four samples had viral loads >1,000 copies/ml. Using a cutoff of 3.0 OD-n the FRR was 5.5% (20/362), with four samples having viral loads <1,000 copies/ml. Factors associated with a higher odds of misclassification were female gender (OR 7.7, 95% CI 1.0-56.4) and being a female sex worker (OR 31.3, 95% CI 4.0-242). At the higher cutoff, being of Zhuang decent, relative to Han, had higher odds of misclassification (OR 6.2, 95% CI 1.99-19.0). The LAg-Avidity assay had a low FRR in this Chinese population. Further investigations of the higher frequency of low LAg-Avidity results seen in female sex workers and individuals of Zhuang descent should be explored in a larger study.
机译：用于HIV横断面检测的检测方法可能会将一些近期未感染HIV的个体误分类为最近感染的个体，从而高估了HIV的发病率。我们使用有限的抗原亲和力测定法（LAg-Avidity）分析了来自广西（中国已知长期感染）的受试者近期错误分类的频率和因素。使用LAg-Avidity对来自中国广西的未接受治疗的个体的存储样品进行了测试。测试了来自已知感染2至13.5年的个体的362个样本，并在不同的检测临界值下确定了假阳性率（FRR）（阳性结果的样本频率）。此外，确定了与分类错误有关的因素。使用1.5归一化光密度单位（OD-n）的截断值，LAg-Avidity的FRR为1.1％（4/362）。所有四个样品的病毒载量均> 1,000拷贝/ ml。使用3.0 OD-n的截断值，FRR为5.5％（20/362），其中四个样品的病毒载量<1,000拷贝/ ml。与错误分类几率较高相关的因素是女性（OR 7.7，95％CI 1.0-56.4）和是女性工作者（OR 31.3，95％CI 4.0-242）。在较高的临界值下，相对于汉族而言，身为壮族的人有较高的错误分类几率（OR 6.2，95％CI 1.99-19.0）。在该中国人群中，LAg亲和力测定的FRR较低。在较大规模的研究中，应进一步调查在女性性工作者和壮族后代中发现的低LAg亲和力结果的较高频率。

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