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首页> 外文期刊>AIDS Research and Human Retroviruses >Short Communication: Natural killer cells and expression of KIR receptors in chronic HIV type 1-infected patients after different strategies of structured therapy interruption.
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Short Communication: Natural killer cells and expression of KIR receptors in chronic HIV type 1-infected patients after different strategies of structured therapy interruption.

机译：简短交流：经过结构疗法中断的不同策略后，慢性1型慢性感染HIV患者的自然杀伤细胞和KIR受体的表达。

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摘要

Few data evaluating the NK cell profile during structured therapy interruption (STI) in chronic HIV-1 infection are available. Changes in NK cell percentages and KIR and NKG2A receptors were analyzed at baseline and after 2 years of follow-up in 121 patients on ART with CD4(+) >450 cells/ml and VL <200 copies/ml randomized in three arms according to the criteria employed to resume ART during STI: virological arm (VA n = 47, VL >30,000 copies/ml or CD4 <350 cells/ml), immunological arm (IA n = 37, CD4< 350 cells/ml), and a control arm (n = 37) in which ART was maintained. After 2 years of follow-up, a decrease in CD3(-)CD56(+) CD16(+) cell percentages in VA and IA patients, but not in CA patients, was observed. Those patients with higher decrease in CD3(-)CD56(+)CD16(+) cells had a higher decrease in CD4(+) cells (r = 0.35, p = 0.001) and higher increase in PVL (r = -0.26, p = 0.02). KIR and NKG2A receptor expression tended to increase in CA and decreased in the other two arms (more in IA than in VA). Patients who displayed a greater decrease in CD4(+) T cells and a greater rise in PVL after 2 years of follow-up had a significantly higher decrease in KIR and NKG2A receptors expressed in CD3(-)CD56(+) cells. Patients who presented the lowest levels of total NK cells and KIR and NKG2A receptor expression after STI showed the poorest virology or immunology outcomes. This finding suggests that STI could decrease the number of NK subsets, which is related to the worst clinical development in these patients.
机译：目前尚无评估慢性HIV-1感染在结构性治疗中断（STI）期间NK细胞谱的数据。在基线时和随访2年后，对121例接受CD4（+）> 450细胞/ ml和VL <200拷贝/ ml的ART患者随机分为3组，分别分析了NK细胞百分比和KIR和NKG2A受体的变化。在STI期间恢复ART所采用的标准：病毒学组（VA n = 47，VL> 30,000拷贝/ ml或CD4 <350细胞/ ml），免疫学组（IA n = 37，CD4 <350细胞/ ml），以及维持ART的对照组（n = 37）。经过2年的随访，在VA和IA患者中观察到CD3（-）CD56（+）CD16（+）细胞百分比降低，但在CA患者中未观察到。 CD3（-）CD56（+）CD16（+）细胞减少程度较高的患者CD4（+）细胞减少程度较高（r = 0.35，p = 0.001），PVL升高程度较高（r = -0.26，p = 0.02）。 KIR和NKG2A受体的表达在CA中趋于升高，而在另两个臂中则趋于降低（IA高于VA）。在随访2年后，CD4（+）T细胞下降幅度更大，PVL上升幅度更大的患者，CD3（-）CD56（+）细胞表达的KIR和NKG2A受体的下降幅度明显更高。 STI后呈现出最低水平的总NK细胞，KIR和NKG2A受体表达的患者显示出最差的病毒学或免疫学结果。这一发现表明性传播感染可以减少NK亚群的数量，这与这些患者的临床发展最差有关。

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