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首页> 外文期刊>Trends in Plant Science >Parallel Transcriptional Regulation of Artemisinin and Flavonoid Biosynthesis
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Parallel Transcriptional Regulation of Artemisinin and Flavonoid Biosynthesis

机译：青蒿素和黄酮类生物合成的平行转录调节

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摘要

Plants regulate the synthesis of specialized compounds through the actions of individual transcription factors (TFs) or sets of TFs. One such compound, artemisinin from Artemisia annua, is widely used as a pharmacological product in the first-line treatment of malaria. However, the emergence of resistance to artemisinin in Plasmodium species, as well as its low production rates, have required innovative treatments such as exploiting the synergistic effects of flavonoids with artemisinin. We overview current knowledge about flavonoid and artemisinin transcriptional regulation in A. annua, and review the dual action of TFs and structural genes that can regulate both pathways simultaneously. Understanding the concerted action of these TFs and their associated structural genes can guide the development of strategies to further improve flavonoid and artemisinin production.
机译：植物通过单个转录因子（TFS）或TFS组的作用来调节专用化合物的合成。 来自Artemisia Annua的一种这样的化合物，来自Arremisia Annua，广泛用作疟疾的一线治疗中的药理产品。 然而，在疟原虫物种以及低生产率中对蒿属素蛋白的抵抗力产生了创新处理，例如利用黄酮类化合物与青蒿素的协同作用。 我们概述了关于Anuana的FlaVOnoid和青蒿素转录调节的现有知识，并审查了TFS和结构基因的双重作用，可以同时调节两种途径。 了解这些TFS的协调一致行为及其相关的结构基因可以指导开发策略，以进一步改善黄酮类化合物和青蒿素生产。

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  • 来源
    《Trends in Plant Science》 |2020年第5期|共11页
  • 作者

    Hassani Danial; Fu Xueqing; Shen Qian; Khalid Muhammad; Rose Jocelyn K. C.; Tang Kexuan;

  • 作者单位

    Shanghai Jiao Tong Univ Sch Agr &

    Biol Plant Biotechnol Res Ctr Fudan SJTU Nottingham Plant Biotechnol R&

    D Ctr Mi Joint Int Res Lab Metab &

    Dev Sci Key Lab Urban A Shanghai 200240 Peoples R China;

    Shanghai Jiao Tong Univ Sch Agr &

    Biol Plant Biotechnol Res Ctr Fudan SJTU Nottingham Plant Biotechnol R&

    D Ctr Mi Joint Int Res Lab Metab &

    Dev Sci Key Lab Urban A Shanghai 200240 Peoples R China;

    Shanghai Jiao Tong Univ Sch Agr &

    Biol Plant Biotechnol Res Ctr Fudan SJTU Nottingham Plant Biotechnol R&

    D Ctr Mi Joint Int Res Lab Metab &

    Dev Sci Key Lab Urban A Shanghai 200240 Peoples R China;

    Shanghai Jiao Tong Univ Sch Agr &

    Biol Key Lab Urban Agr Shanghai 200240 Peoples R China;

    Cornell Univ Sch Integrat Plant Sci Plant Biol Sect Ithaca NY 14853 USA;

    Shanghai Jiao Tong Univ Sch Agr &

    Biol Plant Biotechnol Res Ctr Fudan SJTU Nottingham Plant Biotechnol R&

    D Ctr Mi Joint Int Res Lab Metab &

    Dev Sci Key Lab Urban A Shanghai 200240 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 植物学;
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