Mass Spectrometry Untangles Plant Membrane Protein Signaling Networks

Chen Yanmei; Weckwerth Wolfram

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Mass Spectrometry Untangles Plant Membrane Protein Signaling Networks

机译：质谱法未解压缩植物膜蛋白信号网络

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Plasma membranes (PMs) act as primary cellular checkpoints for sensing signals and controlling solute transport. Membrane proteins communicate with intracellular processes through protein interaction networks. Deciphering these signaling networks provides crucial information for elucidating in vivo cellular regulation. Large-scale proteomics enables system-wide characterization of the membrane proteome, identification of ligand-receptor pairs, and elucidation of signals originating at membranes. In this review we assess recent progress in the development of mass spectrometry (MS)-based proteomic pipelines for determining membrane signaling pathways. We focus in particular on current techniques for the analysis of membrane protein phosphorylation and interaction, and how these proteins may be connected to downstream changes in gene expression, metabolism, and physiology.

机译：血浆膜（PMS）充当用于感测信号和控制溶质转运的主要细胞检查点。膜蛋白通过蛋白质相互作用网络与细胞内过程连通。解密这些信令网络提供了用于阐明体内蜂窝调节的重要信息。大规模蛋白质组学能够能够整态膜蛋白质组的表征，鉴定配体 - 受体对，并阐明源自膜的信号。在该综述中，我们评估了基于质谱（MS）的蛋白质组学管道的开发中的最近进展，用于确定膜信号传导途径。我们特别关注当前用于分析膜蛋白磷酸化和相互作用的技术，以及这些蛋白质如何与基因表达，代谢和生理学的下游变化。

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《Trends in Plant Science》 |2020年第9期|共15页
作者
Chen Yanmei; Weckwerth Wolfram;
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作者单位

China Agr Univ Coll Biol Sci State Key Lab Plant Physiol &

Biochem Beijing 100193 Peoples R China;

Univ Vienna Dept Funct &

Evolutionary Ecol Mol Syst Biol MOSY A-1090 Vienna Austria;

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正文语种 eng
中图分类植物学;
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1. Mass Spectrometry Untangles Plant Membrane Protein Signaling Networks [J] . Chen Yanmei, Weckwerth Wolfram Trends in Plant Science . 2020,第9期

机译：质谱法未解压缩植物膜蛋白信号网络
2. In vivo cross-linking combined with mass spectrometry analysis reveals receptor-like kinases and Ca~(2+) signalling proteins as putative interaction partners of pollen plasma membrane H~+ ATPases [J] . Heidi Pertl-Obermeyer, Waltraud X. Schulze, Gerhard Obermeyer Journal of proteomics . 2014,第Null期

机译：体内交联结合质谱分析揭示受体样激酶和Ca〜（2+）信号蛋白是花粉质膜H〜+ ATPase的假定相互作用伙伴
3. Quantitative analysis of phosphorylation-based protein signaling networks in the immune system by mass spectrometry [J] . Nita-Lazar Aleksandra Wiley interdisciplinary reviews. Systems biology and medicine . 2011,第3期

机译：质谱定量分析免疫系统中基于磷酸化的蛋白信号网络
4. Accurate Quantitative Determination of Plasma Membrane Protein Concentrations in Intact Arabidopsis thaliana Plants using Metabolic Labeling and Mass Spectrometry [C] . Katja Bernfur, Olaf Larsson, Christer Larsson, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：使用代谢标记和质谱法测定完整拟南芥植物中的血浆膜蛋白浓度的准确定量测定
5. Mass Spectrometry-based Strategies for Protein Characterization: Amyloid Formation, Protein- Ligand Interactions and Structures of Membrane Proteins in Live Cells [D] . Li, Ke. 2018

机译：基于质谱的蛋白质表征策略：活细胞中淀粉样蛋白形成，蛋白 - 配体相互作用和膜蛋白的结构
6. From pathways to networks: connecting dots by establishing protein-protein interaction networks in signaling pathways using affinity purification and mass spectrometry [O] . Xu Li, Wenqi Wang, Junjie Chen -1

机译：从途径到网络：通过亲和纯化和质谱在信号传导途径中建立蛋白质-蛋白质相互作用网络来连接点
7. Probing lipidation of membrane active peptides and integral membrane proteins by liquid chromatography-mass spectrometry and ion mobility separation-mass spectrometry [O] . ISMAIL VIANSDIQISMAIL 2017

机译：通过液相色谱 - 质谱和离子淌度分离 - 质谱法探测膜活性肽和整合膜蛋白的脂质化
8. Chemical crosslinking and mass spectrometry studies of the structure and dynamics of membrane proteins and receptors. [R] . 2005

机译：化学交联和质谱研究膜蛋白和受体的结构和动力学。

Mass Spectrometry Untangles Plant Membrane Protein Signaling Networks

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