Contribution of Untargeted Metabolomics for Future Assessment of Biotech Crops

Christ Bastien; Pluskal Tomas; Aubry Sylvain; Weng Jing-Ke

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Contribution of Untargeted Metabolomics for Future Assessment of Biotech Crops

机译：未明确的代谢组学促进生物技术作物的未来评估的贡献

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The nutritional value and safety of food crops are ultimately determined by their chemical composition. Recent developments in the field of metabolomics have made it possible to characterize the metabolic profile of crops in a comprehensive and high-throughput manner. Here, we propose that state-of-the-art untargeted metabolomics technology should be leveraged for safety assessment of new crop products. We suggest generally applicable experimental design principles that facilitate the efficient and rigorous identification of both intended and unintended metabolic alterations associated with a newly engineered trait. Our proposition could contribute to increased transparency of the safety assessment process for new biotech crops.

机译：食物作物的营养价值和安全最终由其化学成分确定。代谢组科领域的最新发展使得以全面和高吞吐量的方式表征作物的代谢概况。在这里，我们建议应利用最先进的未确定的代谢组科技术以促进对新作物产品的安全评估。我们建议通常适用的实验设计原理，促进与新工程特质相关的预期和意外的代谢改变的有效和严谨的鉴定。我们的命题可能有助于提高新生物技术作物的安全评估过程的透明度。

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《Trends in Plant Science》 |2018年第12期|共10页
作者
Christ Bastien; Pluskal Tomas; Aubry Sylvain; Weng Jing-Ke;
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作者单位

Whitehead Inst Biomed Res 9 Cambridge Ctr Cambridge MA 02142 USA;

Whitehead Inst Biomed Res 9 Cambridge Ctr Cambridge MA 02142 USA;

Fed Off Agr CH-3003 Bern Switzerland;

Whitehead Inst Biomed Res 9 Cambridge Ctr Cambridge MA 02142 USA;

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正文语种 eng
中图分类植物学;
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1. Contribution of Untargeted Metabolomics for Future Assessment of Biotech Crops [J] . Christ Bastien, Pluskal Tomas, Aubry Sylvain, Trends in Plant Science . 2018,第12期

机译：未明确的代谢组学促进生物技术作物的未来评估的贡献
2. CROP: correlation-based reduction of feature multiplicities in untargeted metabolomic data [J] . Bioinformatics . 2020,第9期

机译：作物：基于相关的相关性多样性减少在未标准的代谢组数据中
3. Use of ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry system as valuable tool for an untargeted metabolomic profiling of Rumex tunetanus flowers and stems and contribution to the antioxidant activity [J] . Abidi Jouda, Ammar Sonda, Ben Brahim Samia, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2018,第期

机译：使用超高效液相色谱法加上四极 - 飞行时间质谱系统，作为无价化的rumex tunetanus花和茎和茎和抗氧化活性的贡献的有价值的工具
4. Role of Composition and Animal Feeding Studies in the Safety Assessment of Biotech Crops [C] . William P. Ridley, Gary F. Hartnell, Bruce G. Hammond Pan-Pacific Conference on Pesticide Science . 2005

机译：组成和动物饲养研究在生物技术作物安全评估中的作用
5. An assessment of David Hollenbach's contribution to the debate on human rights and its future promise. [D] . Oppong, Joseph. 2010

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6. An Untargeted Metabolomics Approach for Correlating Pulse Crop Seed Coat Polyphenol Profiles with Antioxidant Capacity and Iron Chelation Ability [O] . Fatma M. Elessawy, Albert Vandenberg, Anas El-Aneed, 2021

机译：具有抗氧化能力和铁螯合能力的脉冲作物种子涂层多酚谱相关的未标准性代谢组合方法
7. Contribution of Untargeted Metabolomics for Future Assessment of Biotech Crops [O] . Bastien Christ, Tomáš Pluskal, Sylvain Aubry, 2018

机译：未明确的代谢组合对生物技术作物的未来评估的贡献
8. Water-Quality Assessment of South-Central Texas: Occurrence and Distribution ofVolatile Organic Compounds in Surface Water and Ground Water, 1983-94, and Implications for Future Monitoring. A Contribution of the National Water-Quality Assessment Program [R] . Ging, P. B., Judd, L. J., Wynn, K. H. 1997

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Contribution of Untargeted Metabolomics for Future Assessment of Biotech Crops

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