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DNA-Damaging Effectors: New Players in the Effector Arena

机译:DNA损坏的效果:效应竞技场的新玩家

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摘要

In animal cells, nuclear DNA is the target of genotoxins produced by bacterial pathogens that cause genomic mutations eventually leading to apoptosis, senescence, and carcinogenic development. In response to the insult, the DNA damage response (DDR) is activated to ensure lesion repair. Accumulation of DNA breaks is also detected in plants during microbial infection. In this opinion article we propose that phytopathogens can produce DNA-damaging effectors. The recent identification of a functional genotoxin in devastating eukaryotic plant pathogens, such as oomycetes, supports the concept that DNA-damaging effectors may contribute to pathogenicity. Additionally, this raises the question of how plants can perceive these damages and whether this perception can be connected to the plant immune system.
机译:在动物细胞中,核DNA是通过细菌病原体产生的遗传毒素的靶标,导致基因组突变最终导致细胞凋亡,衰老和致癌发育。 响应损害,激活DNA损伤响应(DDR)以确保病变修复。 在微生物感染期间,在植物中也检测到DNA断裂的积累。 在此意见中,我们提出植物病原体可以产生DNA损伤的效果。 最近在毁灭性的真核植物病原体中鉴定功能性遗留毒素,例如oomycetes,支持DNA损伤效应器可能有助于致病性的概念。 此外,这提出了植物如何感知这些损害以及这种感知如何与植物免疫系统连接的问题。

著录项

  • 来源
    《Trends in Plant Science》 |2019年第12期|共8页
  • 作者单位

    Univ Toulouse CNRS Lab Rech Sci Vegetales UPS Toulouse France;

    Univ Paris Saclay Univ Paris Sud Univ Evry Inst Plant Sci Paris Saclay IPS2 CNRS INRA F-91405 Paris France;

    Univ Toulouse CNRS Lab Rech Sci Vegetales UPS Toulouse France;

    Univ Toulouse CNRS Lab Rech Sci Vegetales UPS Toulouse France;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 植物学;
  • 关键词

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