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首页> 外文期刊>Transplant international : >The postreperfusion syndrome is associated with acute kidney injury following donation after brain death liver transplantation
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The postreperfusion syndrome is associated with acute kidney injury following donation after brain death liver transplantation

机译：在脑死病肝移植后捐赠后，PostreperFusion综合征与急性肾损伤有关

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Summary Acute kidney injury ( AKI ) is frequently observed after donation after brain death ( DBD ) liver transplantation ( LT ) and associated with impaired recipient survival and chronic kidney disease. Hepatic ischemia/reperfusion injury ( IRI ) is suggested to be an important factor in this process. The postreperfusion syndrome ( PRS ) is the first manifestation of severe hepatic IRI directly after reperfusion. We performed a retrospective study on the relation between hepatic IRI and PRS and their impact on AKI in 155 DBD LT recipients. Severity of hepatic IRI was measured by peak postoperative AST levels and PRS was defined as 30% decrease in MAP ≥1 min within 5 min after reperfusion. AKI was observed in 39% of the recipients. AKI was significantly more observed in recipients with PRS (53% vs. 32%; P = 0.013). Median peak AST level was higher in recipients with PRS (1388 vs. 771 U/l; P 0.001). Decrease in MAP after reperfusion correlated well with both severity of AKI ( P = 0.012) and hepatic IRI ( P 0.001). Multiple logistic regression identified PRS as an independent factor for postoperative AKI ( OR 2.28; 95% CI 1.06–4.99; P = 0.035). In conclusion, PRS reflects severe hepatic IRI and predicts AKI after DBD LT . PRS immediately after reperfusion is an early warning sign and creates opportunities to preserve postoperative renal function.
机译：发明内容脑死后捐赠后经常观察急性肾损伤（AKI），并与受体存活率受损和慢性肾病相关联。肝脏缺血/再灌注损伤（IRI）被认为是该过程中的一个重要因素。 PostreperFusion综合征（PRS）是再灌注后直接严重肝IRI的第一个表现。我们对肝脏IRI和PRS与155次DBD LT受者的影响进行了回顾性研究及其对AKI的影响。通过峰值术后AST水平测量肝脏IRI的严重程度，并且在再灌注后5分钟内将PRS定义为≥1分钟≥1分钟。在39％的收件人中观察到AKI。在受试者中，AKI显着观察到PRS（53％与32％; P = 0.013）。中位峰AST水平较高，受害者有PRS（1388 Vs.771 U / L; P <0.001）。再灌注后的地图减少良好均匀均匀性（P = 0.012）和肝IRI（P <0.001）。多元逻辑回归识别PRS作为术后AKI的独立因素（或2.28; 95％CI 1.06-4.99; P = 0.035）。总之，PRS反映了严重的肝脏IRI并在DBD之后预测AKI。 PRS在再灌注后立即是预警标志，并创造了保存术后肾功能的机会。

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