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Metabolic Adaptations to Infections at the Organismal Level

机译:在有机体水平感染的代谢适应

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摘要

Metabolic processes occurring during host-microbiota-pathogen interactions can favorably or negatively influence host survival during infection. Defining the metabolic needs of the three players, the mechanisms through which they acquire nutrients, and whether each participant cooperates or competes with each other to meet their own metabolic demands during infection has the potential to reveal new approaches to treat disease. Here, we review topical findings in organismal metabolism and infection and highlight four emerging lines of investigation: how host-microbiota metabolic partnerships protect against infection; competition for glucose between host and pathogen; significance of infection-induced anorexia; and redefinition of the role of iron during infection. We also discuss how these discoveries shape our understanding of infection biology and their likely therapeutic value.
机译:在宿主微生物酵母 - 病原体相互作用期间发生的代谢过程可以在感染期间有利或负面影响宿主存活。 定义三名球员的代谢需求,他们通过其获得营养成分的机制,以及每个参与者是否相互合作或竞争,以满足他们在感染期间的其自身代谢需求有可能揭示治疗疾病的新方法。 在这里,我们审查了有机体代谢和感染中的局部发现,并突出了四种新兴的调查 - 宿主微生物群代谢伙伴关系如何防止感染; 宿主和病原体之间的葡萄糖竞争; 感染诱导的厌食症的意义; 并重新定义铁在感染过程中的作用。 我们还讨论这些发现如何塑造我们对感染生物学的理解及其可能的治疗价值。

著录项

  • 来源
    《Trends in immunology》 |2020年第2期|共13页
  • 作者

    Troha Katia; Ayres Janelle S.;

  • 作者单位

    Salk Inst Biol Studies Nomis Ctr lmmunobiol &

    Microbial Pathogenesis Gene Express Lab Mol &

    Syst;

    Salk Inst Biol Studies Nomis Ctr lmmunobiol &

    Microbial Pathogenesis Gene Express Lab Mol &

    Syst;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

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