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首页> 外文期刊>Trends in immunology >The Lung Microvasculature Is a Functional Immune Niche
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The Lung Microvasculature Is a Functional Immune Niche

机译:肺部微血管属性是一种功能性免疫力利基

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Lung capillaries, best known for vital gas exchange, also contribute to neutrophil margination, a phenomenon resulting in large numbers of pulmonary vascular neutrophils. Importantly, the functional relevance of neutrophil margination is unknown. Recent advances in microscopy have altered our understanding of why neutrophils marginate. Specifically, data show that lung capillaries provide a unique anatomical site for neutrophils to capture bloodstream pathogens, which contrasts the conventional monophagocytic-dominated vascular host defense of the spleen and liver. Moreover, lung capillaries provide an efficient site for direct cell-cell communication required for the induction of apoptosis in aged neutrophils. These new ideas transform our views of the pulmonary circulation as a site for immediate neutrophil-mediated host defense and regulation of their life cycle.
机译:肺毛细血管,最着名的重要气体交换,也有助于中性粒细胞游击,这是一种导致大量肺血管中性粒细胞的现象。 重要的是,中性粒细胞游击型的功能相关性未知。 显微镜的最新进展改变了我们对为什么中性粒细胞的理解。 具体而言,数据显示肺毛细血管为中性粒细胞提供独特的解剖部位,以捕获血液病原体,对比脾脏和肝脏的常规单噬菌体主导的血管宿主防御造影。 此外,肺毛细血管提供了一种有效的位点,用于诱导老年中性粒细胞诱导细胞凋亡所需的直接细胞单元通信。 这些新思想将肺循环视为肺循环的观点,作为立即中性粒细胞介导的主体防御和其生命周期的监管。

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