Human Secretory IgM: An Elusive Player in Mucosal Immunity

Michaud Eva; Mastrandrea Carmelo; Rochereau Nicolas; Paul Stephane

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Human Secretory IgM: An Elusive Player in Mucosal Immunity

机译：人体分泌IGM：粘膜免疫的难以捉摸的球员

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Secretory IgMs (SIgMs) were amongst the first identified immunoglobulins. However, their importance was not fully understood and recent advances have shown they play a key role in establishing and promoting commensal gut tolerance in mice and humans. The true interactions between SIgMs and the microbiota remain controversial and we aim to consolidate current knowledge in this review. Through comprehensive examination of SIgMs and their corresponding B cell secretors in several different pathological immunological contexts, we review the presumed role of these molecules in gut tolerance, inflammatory bowel diseases, and lung immunity. As SIgMs harbor a mostly tolerogenic function, we posit that their inclusion in further immunological research is paramount.

机译：分泌IgMS（SIGMS）是第一个鉴定的免疫球蛋白。然而，他们的重要性并未完全理解，最近的进展表明他们在建立和促进小鼠和人类的共生肠道耐受性方面发挥着关键作用。 SIGMS与Microbiota之间的真正相互作用仍然存在争议，我们的目标是在本次审查中巩固当前的知识。通过对几种不同病理免疫背景的SIGMS及其相应的B细胞分泌物的综合检查，我们审查了这些分子在肠道耐药性，炎症性肠病和肺免疫中的推定作用。由于SIGMS涉及大多数耐受性功能，我们认为它们在进一步的免疫学研究中的包容是至关重要的。

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《Trends in immunology》 |2020年第2期|共16页
作者
Michaud Eva; Mastrandrea Carmelo; Rochereau Nicolas; Paul Stephane;
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Univ Lyon GIMAP EA3064 CIC Vaccinol 1408 St Etienne France;

Univ Lyon LBTO UMR1059 St Etienne France;

Univ Lyon GIMAP EA3064 CIC Vaccinol 1408 St Etienne France;

Univ Lyon GIMAP EA3064 CIC Vaccinol 1408 St Etienne France;

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正文语种 eng
中图分类医学免疫学;
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1. Human Secretory IgM: An Elusive Player in Mucosal Immunity [J] . Michaud Eva, Mastrandrea Carmelo, Rochereau Nicolas, Trends in immunology . 2020,第2期

机译：人体分泌IGM：粘膜免疫的难以捉摸的球员
2. Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut [J] . Chairatana Phoom, Nolan Elizabeth M. Critical Reviews in Biochemistry and Molecular Biology . 2017,第1a6期

机译：防御素，凝集素，粘蛋白和分泌物免疫球蛋白A：微生物结合生物分子有助于人体肠道中的粘膜免疫力
3. Detection of secretory immunoglobulin a in human colostrum as mucosal immune response against proteins of the type III secretion system of Salmonella, Shigella and enteropathogenic Escherichia Coli [J] . DurandD., OchoaT.J., BellomoS.M.E., The Pediatric infectious disease journal . 2013,第10期

机译：检测人初乳中分泌的免疫球蛋白a，作为针对沙门氏菌，志贺氏菌和肠道致病性大肠杆菌的III型分泌系统蛋白的粘膜免疫应答
4. Counter-regulation in the mucosal immune system and the mechanism of mucosal inflammation [C] . W. STROBER, I. FUSS, A. KITANI Falk Symposium . 2000

机译：粘膜免疫系统的反调节与粘膜炎症的机制
5. Setting the Stage for a Potential Varicella-Zoster Virus (VZV)-Based HIV Vaccine: Characterization of the Mucosal Immune Response Induced by VZV Vaccination in Humans [D] . Perciani, Catia Taniela. 2019

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6. Human Immunodeficiency Virus Type 1 Stimulates the Expression and Production of Secretory Leukocyte Protease Inhibitor (SLPI) in Oral Epithelial Cells: a Role for SLPI in Innate Mucosal Immunity [O] . N. K. Jana, L. R. Gray, D. C. Shugars 2005

机译：1型人类免疫缺陷病毒刺激口腔上皮细胞中分泌型白细胞蛋白酶抑制剂（SLPI）的表达和生产：SLPI在先天黏膜免疫中的作用
7. Human Immunodeficiency Virus Type 1 Stimulates the Expression and Production of Secretory Leukocyte Protease Inhibitor (SLPI) in Oral Epithelial Cells: a Role for SLPI in Innate Mucosal Immunity [O] . Jana, N. K., Gray, L. R., Shugars, D. C. 2005

机译：1型人类免疫缺陷病毒刺激口腔上皮细胞中分泌型白细胞蛋白酶抑制剂（SLPI）的表达和生产：SLPI在先天黏膜免疫中的作用

Human Secretory IgM: An Elusive Player in Mucosal Immunity

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