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首页> 外文期刊>Trends in immunology >Towards Immunotherapy for Pediatric Brain Tumors
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Towards Immunotherapy for Pediatric Brain Tumors

机译:对儿科脑肿瘤的免疫疗法

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摘要

Pediatric brain tumors are the leading cause of childhood cancer-related death. Immunotherapy is a powerful new approach for treating some refractory cancers; applying this ` fourth pillar' of cancer treatment to pediatric brain tumors is an exciting but challenging prospect. This review offers new perspectives on moving towards successful immunotherapy for pediatric brain tumors, focusing on pediatric high-grade glioma (HGG), a subgroup with universally poor outcomes. We cover chimeric antigen receptor T cell (CAR-T) therapy, vaccine therapy, and checkpoint inhibition in this context, and focus on the need for intimately understanding the growing brain and its immune system. We highlight the challenges associated with the application of immunotherapy in pediatric neuro-oncology, as well as the tissue-specific challenges to be overcome, to achieve improved outcomes.
机译:小儿脑肿瘤是儿童癌症相关死亡的主要原因。 免疫疗法是一种治疗一些难治性癌症的强大新方法; 将癌症治疗应用于小儿脑肿瘤的“第四柱”是一种令人兴奋但挑战性的前景。 本次审查提供了用于对儿科脑肿瘤成功免疫疗法的新观点,重点关注儿科高级胶质瘤(HGG),一个具有普遍差的结果的亚组。 我们在这种情况下覆盖嵌合抗原受体T细胞(Car-T)治疗,疫苗治疗和检查点抑制,并专注于亲密地理解生长大脑及其免疫系统的需求。 我们突出了与免疫疗法在儿科神经肿瘤中应用相关的挑战,以及克服的组织特定挑战,以实现改善的结果。

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