...
首页> 外文期刊>Trends in immunology >The Cellular Immunotherapy Revolution: Arming the Immune System for Precision Therapy
【24h】

The Cellular Immunotherapy Revolution: Arming the Immune System for Precision Therapy

机译:细胞免疫治疗革命:武装免疫系统进行精密治疗

获取原文
获取原文并翻译 | 示例
           

摘要

Immunotherapy treatments harnessing the patient's immune system herald a new era of personalized medicine, offering hope for curative responses in patients with serious illnesses. Cell-mediated immunity can eliminate cancer cells and provide durable remissions. This often relies on repurposing cytotoxic T cell activity through modified T cell receptors or chimeric antigen receptors. Furthermore, synthetic biology has expanded the cell engineering toolkit to provide immune cells with more functionality, including disease targeting, potency, and safety. We focus on T cell-based immunotherapy, highlighting discoveries of genetic engineering and therapeutic use. We also examine emerging paths that could be undertaken to improve this novel class of drugs, and discuss the challenges of toxicities as well as other limitations of cellular immunotherapy.
机译:免疫疗法治疗利用患者的免疫系统预示着一个新的个性化医学时代,为严重疾病患者提供了治疗反应的希望。 细胞介导的免疫可以消除癌细胞并提供持久的解除。 这通常依赖于通过改性的T细胞受体或嵌合抗原受体重新筛选细胞毒性T细胞活性。 此外,合成生物学扩增了细胞工程工具包,以提供具有更多功能的免疫细胞,包括疾病靶向,效力和安全性。 我们专注于基于T细胞的免疫疗法,突出了基因工程和治疗用途的发现。 我们还研究了可以进行的新兴道路,以改善这类新颖的药物,并讨论毒性的挑战以及细胞免疫疗法的其他限制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号