Skin-Resident Innate Lymphoid Cells-Cutaneous Innate Guardians and Regulators

Kobayashi Tetsuro; Ricardo-Gonzalez Roberto R.; Moro Kazuyo

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Skin-Resident Innate Lymphoid Cells-Cutaneous Innate Guardians and Regulators

机译：皮肤居住的先天淋巴细胞 - 皮肤先天监护人和监管机构

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Skin is the largest barrier organ and an important interface between the body and the outside environment. Immune surveillance and homeostatic regulation of skin function are governed by complex interactions between resident lymphoid and myeloid cells and their communications with the surrounding parenchyma. Recent studies have provided exciting insights about the unique characteristics of skin-resident innate lymphoid cells (ILCs). Here, we discuss advances demonstrating how skin ILCs contribute to tissue homeostasis by regulating microbiome balance in steady-state and how their dysregulation can trigger and promote inflammatory skin diseases such as atopic dermatitis and psoriasis. We review the phenotypic and functional similarities and differences of ILCs between the skin and other organs and highlight future areas of investigation for this field.

机译：皮肤是最大的屏障器官和身体与外部环境之间的重要界面。皮肤功能的免疫监测和稳态调节受居民淋巴和骨髓细胞之间的复杂相互作用及其与周围实质的通信。最近的研究提供了关于皮肤居住的先天淋巴细胞（ILC）独特特征的令人兴奋的见解。在这里，我们讨论展示皮肤ILCS如何通过调节稳态的微生物组平衡以及他们的呼吸困难如何触发和促进特应性皮炎和牛皮癣等炎症性皮肤病来对组织稳态有助于组织稳态的进展。我们审查了皮肤和其他器官之间ILC的表型和功能相似性和差异，并突出了该领域的未来调查领域。

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来源
《Trends in immunology》 |2020年第2期|共13页
作者
Kobayashi Tetsuro; Ricardo-Gonzalez Roberto R.; Moro Kazuyo;
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作者单位

RIKEN Ctr Integrat Med Sci IMS Lab Innate Immune Syst Tsurumi Ku 1-7-22 Suehiro Cho Yokohama;

Univ Calif San Francisco Dept Dermatol San Francisco CA 94143 USA;

RIKEN Ctr Integrat Med Sci IMS Lab Innate Immune Syst Tsurumi Ku 1-7-22 Suehiro Cho Yokohama;

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正文语种 eng
中图分类医学免疫学;
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1. Skin-Resident Innate Lymphoid Cells-Cutaneous Innate Guardians and Regulators [J] . Kobayashi Tetsuro, Ricardo-Gonzalez Roberto R., Moro Kazuyo Trends in immunology . 2020,第2期

机译：皮肤居住的先天淋巴细胞 - 皮肤先天监护人和监管机构
2. JAK JAK / STAT STAT signaling in regulation of innate lymphoid cells: The gods before the guardians [J] . Stabile Helena, Scarno Gianluca, Fionda Cinzia, Immunological reviews. . 2018,第1期

机译：jak jak / stat stat信令在先天淋巴细胞的调节中：监护人面前的众神
3. Reduction of circulating innate lymphoid cell progenitors results in impaired cytokine production by innate lymphoid cells in patients with lupus nephritis [J] . Seungwon Ryu, Eun Young Lee, Dong Ki Kim, Arthritis research & therapy. . 2020,第1期

机译：循环先天淋巴细胞祖细胞的减少导致狼疮肾炎患者的先天淋巴细胞产生的细胞因子产生受损
4. Stochastic secretion response to transient stimulus of group-2 innate lymphoid cells (ILC2) [C] . Kazuki Yoda, Kaede Miyata, Nobutake Suzuki, International Symposium on Micro-NanoMechatronics and Human Science . 2017

机译：对第2组先天性淋巴样细胞（ILC2）瞬时刺激的随机分泌反应
5. TL1A Is a Central Regulator of Group 3 Innate Lymphoid Cell Function in Colitis [D] . Castellanos, Jim Gonzalez. 2018

机译：TL1A是结肠炎第3组先天淋巴细胞功能的中央调节因子
6. JAK/STAT signaling in regulation of innate lymphoid cells: the godsbefore the guardians [O] . Helena Stabile, Gianluca Scarno, Cinzia Fionda, -1

机译：JAK / STAT信号调节先天淋巴样细胞：诸神在监护人面前
7. JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians [O] . Helena Stabile, Gianluca Scarno, Cinzia Fionda, 2018

机译：jak / stat信号传导在先天淋巴细胞的调节中：监护人面前的众神

Skin-Resident Innate Lymphoid Cells-Cutaneous Innate Guardians and Regulators

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