Rethinking Thymic Tolerance: Lessons from Mice

Inglesfield Sarah; Cosway Emilie J.; Jenkinson William E.; Anderson Graham

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Rethinking Thymic Tolerance: Lessons from Mice

机译：重新思考胸腺耐受性：小鼠的课程

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In the thymus, distinct cortex and medulla areas emphasize the division of labor in selection events shaping the alpha beta T cell receptor repertoire. For example, MHC restriction via positive selection is a unique property of epithelial cells in the thymic cortex. Far less clear are the events controlling tolerance induction in the medulla. By acting in concert through multiple roles, including antigen production/presentation and chemokine-mediated control of migration, we propose that medullary epithelium and dendritic cells collectively enable the medulla to balance T cell production with negative selection and Foxp3(+) regulatory T cell (Treg) development. We examine here the features of these medullary resident cells and their roles in T cell tolerance, and discuss how imbalance in the thymus can result in loss of T cell tolerance.

机译：在胸腺中，不同的皮质和髓质区域强调了塑造αβT细胞受体曲目的选择事件中的劳动分工。例如，通过阳性选择MHC限制是胸腺皮质中上皮细胞的独特性质。更清楚的是控制髓质耐受性诱导的事件。通过在音乐会通过多种作用，包括抗原产生/呈递和趋化因子介导的迁移控制，我们提出髓质上皮和树突细胞共同使髓质能够使用阴性选择和Foxp3（+）调节T细胞来平衡T细胞产生的培养生产（ Treg）发展。我们在此检查这些髓质常驻细胞的特征及其在T细胞耐受中的作用，并讨论胸腺中的不平衡如何导致T细胞容差的损失。

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来源
《Trends in immunology》 |2019年第4期|共13页
作者
Inglesfield Sarah; Cosway Emilie J.; Jenkinson William E.; Anderson Graham;
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作者单位

Univ Birmingham Med Sch Inst Immunol &

Immunotherapy Birmingham W Midlands England;

Univ Birmingham Med Sch Inst Immunol &

Immunotherapy Birmingham W Midlands England;

Univ Birmingham Med Sch Inst Immunol &

Immunotherapy Birmingham W Midlands England;

Univ Birmingham Med Sch Inst Immunol &

Immunotherapy Birmingham W Midlands England;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
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1. Rethinking Thymic Tolerance: Lessons from Mice [J] . Inglesfield Sarah, Cosway Emilie J., Jenkinson William E., Trends in immunology . 2019,第4期

机译：重新思考胸腺耐受性：小鼠的课程
2. Breakdown of T cell tolerance and autoimmunity in primary immunodeficiency--lessons learned from monogenic disorders in mice and men. [J] . Westerberg LS, Klein C, Snapper SB Current opinion in immunology . 2008,第6期

机译：原发性免疫缺陷中T细胞耐受性和自身免疫性的分解-从小鼠和男性的单基因疾病中吸取的教训。
3. Role of cytokines in transplantation tolerance: lessons learned from gene-knockout mice. [J] . Lakkis FG Journal of the American Society of Nephrology: JASN . 1998,第12期

机译：细胞因子在移植耐受性中的作用：从基因敲除小鼠中学到的经验教训。
4. Differences of molecular alteration between radiation-induced and N-ethyl-7V-nitrosourea-induced thymic lymphomas in B6C3F1 mice [C] . Shizuko Kakinum, Mayumi Nishimur, Ayumi Kubo, International Symposium of Radiation and Homeostasis . 2002

机译：B6C3F1小鼠辐射诱导和N-乙基-7V-亚硝基脲植物诱导胸腺淋巴瘤的分子变化的差异
5. Rethinking Aesthetic Concepts: Lessons from the Art of Classical Dressage [D] . Berrier, Monica Jean 2011

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6. Immunological tolerance and tumor rejection in embryo-aggregated chimeric mice – Lessons for tumor immunity [O] . Alexander Y Wagner, Eric Holle, Lori Holle, 2008

机译：胚胎聚集的嵌合小鼠的免疫耐受性和肿瘤排斥反应–肿瘤免疫的教训
7. Immunological tolerance and tumor rejection in embryo-aggregated chimeric mice – Lessons for tumor immunity [O] . Alexander Y Wagner, Eric Holle, Lori Holle, 2008

机译：胚胎聚集的嵌合小鼠的免疫耐受性和肿瘤排斥反应–肿瘤免疫的教训
8. Osteopetrosis Associated with Premature Thymic Involution in Grey-Lethal Mice. In Vitro Studies of Thymic Microenvironment [R] . Wiktor-Jedrzejczak, W., Grzybowski, J., Ahmed, A., 1983

机译：骨质疏松症与灰色致死小鼠早产胸腺退化相关。胸腺微环境的体外研究

Rethinking Thymic Tolerance: Lessons from Mice

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