Chronic Immune Activation in TB/HIV Co-infection

Sharan Riti; Bucsan Allison N.; Ganatra Shashank; Paiardini Mirko; Mohan Mahesh; Mehra Smriti; Khader Shabaana A.; Kaushal Deepak

首页> 外文期刊>Trends in Microbiology >Chronic Immune Activation in TB/HIV Co-infection

【24h】

Chronic Immune Activation in TB/HIV Co-infection

机译：TB / HIV共感染慢性免疫激活

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

HIV co-infection is the most critical risk factor for the reactivation of latent tuberculosis (TB) infection (LTBI). While CD4(+) T cell depletion has been considered the major cause of HIV-induced reactivation of LTBI, recent work in macaques co-infected with Mycobacterium tuberculosis (Mtb)/simian immunodeficiency virus (SIV) suggests that cytopathic effects of SIV resulting in chronic immune activation and dysregulation of T cell homeostasis correlate with reactivation of LTBI. This review builds on compelling data that the reactivation of LTBI during HIV co-infection is likely to be driven by the events of HIV replication and therefore highlights the need to have optimum translational interventions directed at reactivation due to co-infection.

机译：HIV共同感染是潜在结核病（TB）感染（LTBI）重新激活最关键的危险因素。虽然CD4（+）T细胞耗竭被认为是HIV诱导的艾滋病毒诱导的重新激活的主要原因，但近期与结核分枝杆菌（MTB）/ Simian免疫缺陷病毒（SIV）共感染的猕猴（SIV）的作用表明SIV的细胞病变作用导致 T细胞稳态的慢性免疫激活和缺点与LTBI重新激活相关。本综述构建了令人兴奋的数据，即HIV共感染期间LTBI的重新激活可能是由HIV复制事件驱动的，因此突出了由于共感染而具有可重新激活的最佳平移干预的需要。

著录项

来源
《Trends in Microbiology》 |2020年第8期|共14页
作者
Sharan Riti; Bucsan Allison N.; Ganatra Shashank; Paiardini Mirko; Mohan Mahesh; Mehra Smriti; Khader Shabaana A.; Kaushal Deepak;
展开▼
作者单位

Texas Biomed Res Inst Southwest Natl Primate Res Ctr San Antonio TX 78227 USA;

Uniformed Serv Univ Hlth Sci Dept Microbiol &

Immunol Bethesda MD 20814 USA;

Texas Biomed Res Inst Southwest Natl Primate Res Ctr San Antonio TX 78227 USA;

Emory Univ Sch Med Yerkes Natl Primate Res Ctr Atlanta GA 30329 USA;

Texas Biomed Res Inst Southwest Natl Primate Res Ctr San Antonio TX 78227 USA;

Tulane Univ Sch Med Tulane Natl Primate Res Ctr Covington LA 70433 USA;

Washington Univ Sch Med Dept Mol Microbiol St Louis MO 63110 USA;

Texas Biomed Res Inst Southwest Natl Primate Res Ctr San Antonio TX 78227 USA;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类微生物学;
关键词

相似文献

外文文献
中文文献
专利

1. Chronic Immune Activation in TB/HIV Co-infection [J] . Sharan Riti, Bucsan Allison N., Ganatra Shashank, Trends in Microbiology . 2020,第8期

机译：TB / HIV共感染慢性免疫激活
2. Natural killer cell activation distinguishes Mycobacterium tuberculosis-mediated immune reconstitution syndrome from chronic HIV and HIV/MTB coinfection. [J] . Conradie F, Foulkes AS, Ive P, JAIDS: Journal of acquired immune deficiency syndromes . 2011,第3期

机译：自然杀伤细胞的激活将结核分枝杆菌介导的免疫重建综合症与慢性HIV和HIV / MTB合并感染区分开来。
3. Liver fibrosis, microbial translocation and immune activation markers in HIV and HCV infections and in HIV/HCV co-infection [J] . Sacchi Paolo, Cima Serena, Corbella Marta, Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver . 2015,第3期

机译：HIV和HCV感染以及HIV / HCV合并感染中的肝纤维化，微生物易位和免疫激活标志物
4. Systems Biology and Systems Pharmacology Approaches to HIV Infection and TB/HIV Co-Infection [C] . Elsje Pienaar AIChE Annual Meeting . 2016

机译：系统生物学和系统药理学方法艾滋病毒感染和TB / HIV共感染
5. Regulatory T Cells and Immune Activation in the Mucosa During Chronic HIV- and SIV- Infection: Evidence for Immune-mediated Suppression During Progressive Infection [D] . Shaw, Julia Marie 2011

机译：慢性HIV和SIV感染过程中粘膜中的调节性T细胞和免疫激活：渐进感染过程中免疫介导的抑制的证据。
6. Natural Killer cell activation distinguishes M. tuberculosis-mediated Immune reconstitution syndrome (IRIS) from chronic HIV and HIV-MTB co-infection [O] . F. Conradie, A.S. Foulkes, P. Ive, -1

机译：自然杀手细胞活化区分慢性艾滋病毒和HIV-MTB共感染的肺结核介导的免疫重建综合征（IRIS）
7. Immune Activation at Sites of HIV/TB Co-Infection Contributes to the Pathogenesis of HIV-1 Disease. [O] . Qinglai Meng, Ismail Sayin, David H Canaday, 2016

机译：HIV / TB共感染部位的免疫激活有助于HIV-1疾病的发病机制。

Chronic Immune Activation in TB/HIV Co-infection

摘要

著录项

相似文献

相关主题

期刊订阅