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Eat in or Take out? Metabolism of Intracellular Salmonella enterica

机译:吃饭或拿出? 细胞内沙门氏菌的新陈代谢

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Salmonella enterica is an important gastrointestinal and facultative intracellular pathogen. After invasion of host cells, it resides in a specialized, replication-permissive compartment, the Salmonella-containing vacuole (SCV). During maturation of the SCV, Salmonella remodels the host endosomal system to form a variety of membranous extensions from the SCV, one type designated Salmonella-induced filaments (SIFs). It was long unclear how Salmonella is able to sustain replication within the SCV, thought to be a nutrient-poor environment. Recent studies started to characterize the metabolic pathways used by intracellular Salmonella. Besides, new insights into the ultrastructure and biogenesis of SIFs and their essential role in nutrition were obtained lately. Here, we review the recent progress with focus on observations gained by various cellular models.
机译:Salmonella肠道是一种重要的胃肠道和伴伴细胞内病原体。 在宿主细胞侵袭后,它存在于专用复制允许隔室,含沙门氏菌的液体(SCV)。 在SCV成熟期间,沙门氏菌重塑宿主内体系统,形成来自SCV的各种膜延伸,一种指定的沙门氏菌诱导的细丝(SIFS)。 目前尚不清楚沙门氏菌能够在SCV内维持复制,被认为是营养不良的环境。 最近的研究开始表征细胞内沙门氏菌使用的代谢途径。 此外,最近获得了对SIFS超微结构和生物发生的新见解及其在营养中的基本作用。 在这里,我们审查了最近的进展,重点是各种蜂窝模型所获得的观察。

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