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Using Serology to Anticipate Measles Post-honeymoon Period Outbreaks

机译:使用血清学预期麻疹后蜜月期爆发

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Measles vaccination is a public health 'best buy', with the highest cost of illness averted of any vaccine-preventable disease (Ozawa et al., Bull. WHO 2017; 95:629). In recent decades, substantial reductions have been made in the number of measles cases, with an estimated 20 million deaths averted from 2000 to 2017 (Dabbagh et al., MMWR 2018;67:1323). Yet, an important feature of epidemic dynamics is that large outbreaks can occur following years of apparently successful control (Mclean et al., Epidemiol. Infect. 1988;100: 419-442). Such 'post-honeymoon period' outbreaks are a result of the nonlinear dynamics of epidemics (Mclean et al., Epidemiol. Infect. 1988; 100:419-442). Anticipating post-honeymoon outbreaks could lead to substantial gains in public health, helping to guide the timing, age-range, and location of catch-up vaccination campaigns (Grais et al., J. Roy. Soc. Interface 2008003B6:67-74). Theoretical conditions for such outbreaks are well understood for measles, yet the information required to make these calculations policy-relevant is largely lacking. We propose that a major extension of serological studies to directly characterize measles susceptibility is a high priority.
机译:麻疹疫苗接种是一项公共卫生“百思买”,以避免任何疫苗可预防疾病的疾病的成本最高(小泽等人,公牛WHO 2017年; 95:629。)。近几十年来,大幅度减少了在麻疹病例数制成,具有避免二零零零年至2017年,预计有20只万人死亡(达巴​​格等,MMWR 2018年67:1323)。然而,流行动态的一个重要特征是大爆发,可能会发生接下来的几年明显成功的控制(McLean等,流行病学杂志1988年传染; 100:。419-442)。这种“后蜜月期”暴发流行的非线性动力学的结果(McLean等人,传染流行病学杂志1988; 100:。419-442)。预计后期蜜月暴发可能导致公共健康大有斩获,帮助指导追赶疫苗接种活动的时间,年龄范围和位置(Grais等人,J.罗伊志接口2008003B6:。67-74 )。这种爆发的理论条件都很好理解麻疹,但进行这些计算政策相关规定的资料十分匮乏。我们建议,血清学研究的一个重要延伸,直接特征分析麻疹易感是一个高优先级。

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