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RNA-Targeted Antiviral Immunity: More Than Just RNA Silencing

机译:RNA靶向抗病毒免疫:不仅仅是RNA沉默

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摘要

RNA silencing is a fundamental, evolutionarily conserved mechanism that regulates gene expression in eukaryotes. It also functions as a primary immune defense in microbes, such as viruses in plants. In addition to RNA silencing, RNA decay and RNA quality-control pathways are also two ancestral forms of intrinsic antiviral immunity, and the three RNA-targeted pathways may operate cooperatively for their antiviral function. Plant viruses encode viral suppressors of RNA silencing (VSRs) to suppress RNA silencing and facilitate virus infection. In response, plants may activate a counter-counter-defense mechanism to cope with VSR-mediated RNA silencing suppression. In this review, we summarize current knowledge of RNA silencing, RNA decay, and RNA quality control in antiviral defense, and highlight the mechanisms by which viruses compromise RNA-targeted immunity for their infection and survival in plants.
机译:RNA沉默是一种基本,进化的保守机制,调节真核生物中的基因表达。 它还用作微生物中的主要免疫防御,例如植物中的病毒。 除了RNA沉默,RNA衰减和RNA质量控制途径也是两种祖先形式的内在抗病毒免疫,并且三种RNA靶向途径可以合作地用于其抗病毒功能。 植物病毒编码RNA沉默(VSR)的病毒抑制剂,以抑制RNA沉默并促进病毒感染。 作为响应,植物可以激活反逆向防御机制以应对VSR介导的RNA沉默抑制。 在本次审查中,我们总结了目前在抗病毒防御中的RNA沉默,RNA衰减和RNA质量控制的目前了解,并突出了病毒损害了RNA靶向免疫的机制在植物中感染和存活的机制。

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