The Helicobacter pylori Cag Type IV Secretion System

Cover Timothy L.; Lacy D. Borden; Ohi Melanie D.

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The Helicobacter pylori Cag Type IV Secretion System

机译：幽门螺杆菌CAG型IV分泌系统

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Colonization of the human stomach with Helicobacter pylori strains containing the cag pathogenicity island is a risk factor for development of gastric cancer. The cag pathogenicity island contains genes encoding a secreted effector protein (CagA) and components of a type IV secretion system (Cag T4SS). The molecular architecture of the H. pylori Cag T4SS is substantially more complex than that of prototype T4SSs in other bacterial species. In this review, we discuss recent discoveries pertaining to the structure and function of the Cag T4SS and its role in gastric cancer pathogenesis.

机译：含有CAG致病性岛的幽门螺杆菌菌株的人类胃的定植是胃癌发育的危险因素。 CAG致病性岛含有编码分泌的效应蛋白（CAGA）的基因和IV型分泌系统（CAG T4S）。 H.Pylori CAG T4SS的分子结构比其他细菌种类中的原型T4ss的分子结构比较复杂。在本综述中，我们讨论了最近关于CAG T4SS的结构和功能的发现及其在胃癌发病机制中的作用。

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《Trends in Microbiology》 |2020年第8期|共14页
作者
Cover Timothy L.; Lacy D. Borden; Ohi Melanie D.;
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作者单位

Vanderbilt Univ Sch Med Dept Med Nashville TN 37212 USA;

Vanderbilt Univ Sch Med Dept Pathol Microbiol &

Immunol Nashville TN 37212 USA;

Univ Michigan Life Sci Inst Ann Arbor MI 48109 USA;

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正文语种 eng
中图分类微生物学;
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1. Cag-delta (Cag3) protein from the Helicobacter pylori 26695 cag type IV secretion system forms ring-like supramolecular assemblies [J] . Smart Jonathan, Fouillen Aurelien, Casu Bastien, FEMS Microbiology Letters . 2017,第1期

机译：来自幽门螺杆菌26695 CAG IV分泌系统的CAG-DELTA（CAG3）蛋白质形成环状超分子组件
2. Temporal Control of the Helicobacter pylori Cag Type IV Secretion System in a Mongolian Gerbil Model of Gastric Carcinogenesis [J] . Aung Soe Lin, Mark S. McClain, Amber C. Beckett, MBio . 2020,第3期

机译：<命名含量含量型=“属型”>幽门螺杆菌幽门螺杆菌胃癌胃癌模型中的幽门螺杆菌幽门螺杆菌和术语分泌系统
3. In Situ Molecular Architecture of the Helicobacter pylori Cag Type IV Secretion System [J] . Bo Hu, Pratick Khara, Liqiang Song, MBio . 2019,第3期

机译：幽门螺杆菌 Cag IV型分泌系统的原位分子结构
4. Identification of Helicobacter pylori proteins involved in the cag Type-IV secretion system apparatus via discovery and targeted mass spectrometry approaches [C] . Carrie L. Shaffer, W. Hayes McDonald, Salisha Hill, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：通过发现和靶向质谱方法鉴定CAG型-IV分泌系统装置中涉及的幽门螺杆菌蛋白
5. Characterization of the cag type IV secretion system and unique filaments of Helicobacter pylori [D] . Couturier, Marc Roger 2008

机译：IV型cag分泌系统的特征和幽门螺杆菌的独特细丝
6. Cag3 Is a Novel Essential Component of the Helicobacter pylori Cag Type IV Secretion System Outer Membrane Subcomplex [O] . Delia M. Pinto-Santini, Nina R. Salama 2009

机译：Cag3是幽门螺杆菌Cag IV型分泌系统外膜亚复合物的新型必需成分。
7. Cag3 Is a Novel Essential Component of the Helicobacter pylori Cag Type IV Secretion System Outer Membrane Subcomplex ▿ † [O] . Pinto-Santini, Delia M., Salama, Nina R. 2009

机译：Cag3是幽门螺杆菌Cag IV型分泌系统外膜亚复合物的新型必需成分▿†

The Helicobacter pylori Cag Type IV Secretion System

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