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首页> 外文期刊>Tropical Animal Health and Production >Anticoccidial effects of Khaya senegalensis aqueous stem bark extract on broiler chickens experimentally infected with Eimeria species
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Anticoccidial effects of Khaya senegalensis aqueous stem bark extract on broiler chickens experimentally infected with Eimeria species

机译：Khaya Senegalensis含水干树皮提取物对Eimeria物种进行实验感染的肉鸡鸡的抗痛作用

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摘要

Graded concentrations (200, 400 and 800 mg/kg) of the aqueous stem bark extract of Khaya senegalensis was evaluated for its therapeutic efficacy against experimentally induced coccidiosis in broiler chicken. The phytochemical analysis shows the presence of tannins, saponins, cardiac glycosides and steroids. There was significant reduction in oocyst count across the groups in a graded dose manner with 800 mg/kg being the most efficacious dose. There was also weight gain across the treatment groups with immuno-modulatory and erythropoetic activities observed. Also, a significant (p < 0.05) graded dose-dependent reduction in the oocyst count in the treatment groups. A significant (p < 0.05) increase in mean weight gain was also recorded across the experimental groups except the negative control. The haematology also showed a dose-dependent increase in red blood cells, haemoglobin and packed cell volume of the treatment groups. The extract had no significant difference (p > 0.05) on the white blood cells, but a slight decrease in the white blood cells and heterophil counts was observed at 400 mg/kg. Furthermore, the aspartate amino transaminase level showed a significant difference (p < 0.05). Fluctuating levels of other serum biochemical parameters such as total protein, albumin and potassium were observed. No significant difference (p > 0.05) in the sodium concentration was observed. In addition, oxidative stress biomarkers such as catalase significantly increased (p < 0.05) in all the experimental groups in addition to the concomitant increase in reduced gluthathione (GSH) and superoxide dismutase (SOD) levels. Conclusively, the aqueous extract of K. senegalensis was effective in the management of coccidiosis thus supporting its folkloric use.
机译：评估浓度（200,400和800mg / kg）Khaya senegalensis的水茎树皮提取物，在肉鸡鸡肉中针对实验诱导的椰子症进行治疗疗效评价。植物化学分析显示了单宁，皂苷，心糖苷和类固醇的存在。以800mg / kg为最有效的剂量，以渐进剂量的方式显着降低卵囊计数。观察免疫调节和促红细胞病变活动的治疗组中还有体重增加。此外，在治疗组中的卵囊计数中显着（P <0.05）分级剂量依赖性减少。除了阴性对照之外，还记录了除阴性对照之外的实验组的显着（P <0.05）的平均重量增加。血液学还显示出红细胞，血红蛋白和治疗组包装细胞体积的剂量依赖性增加。萃取物在白细胞上没有显着差异（p> 0.05），但在400mg / kg下观察到白细胞和异交计数的轻微降低。此外，天冬氨酸氨基转氨酶水平显示出显着差异（P <0.05）。观察到其他血清生物化学参数的波动水平，例如总蛋白，白蛋白和钾。观察到钠浓度的显着差异（p> 0.05）。此外，除了伴随的FluthAthione（GSH）和超氧化物歧化酶（SOD）水平的伴随增加之外，所有实验组中，氧化应激生物标志物如过氧化氢酶，除了伴随的伴随的伴随的伴随增加。结论，K.Senegalensis的水质提取物在携孢子虫病的管理方面是有效的，因此支持其民俗用途。

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