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The comparative effects of dietary monensin and propylene glycol on insulin resistance of transition dairy cows

机译：膳食宫蛋白和丙二醇对转型乳奶牛胰岛素抵抗的比较效果

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During the transition period, dairy cows suffer from negative energy balance due to the upcoming insulin resistance as a major metabolic disturbance. We hypothesized that providing glucose precursors for transition dairy cows may reduce the insulin resistance. In this study, 24 multiparous Holstein dairy cows were enrolled 8 weeks prior to parturition and divided into 4 equal groups, including control (Ctrl), monensin (Mo), propylene glycol (PPG), and monensin plus propylene glycol (Mo + PPG). Cows from the Mo and PPG groups received 1 mg/kg body weight (BW) of monensin, daily. Cows from the PGG group received 150 g of propylene glycol, daily. Cows from the Mo + PPG group received 1 mg/kg BW of monensin and 150 g/head of propylene glycol daily and Ctrl cows received basal diet without any supplementations. Intravenous glucose tolerance test (ivGTT) was conducted weekly from 3 weeks before to 3 weeks after parturition to evaluate the insulin resistance phenomenon. Immediately after glucose administration, glucose and insulin increased significantly, and their alterations were significant during the study. Glucose and insulin were significantly higher in the Ctrl group than in the other groups, and their levels in different pre- and post-partum periods were significantly lower in the Mo + PPG group than in the other studied groups. The results of this study represented that the supplementary feeding with propionate precursors, such as monensin and propylene glycol, reduced the insulin resistance in dairy cows during the transition period. This effect is more explicit by propylene glycol than by monensin, and the combination of both reduces insulin resistance at higher rates. The use of these dietary supplements is likely to produce more propionates as the main precursor of glucose; therefore, it reduces the negative energy balance and subsequently decreases the insulin resistance. In this regard, to reduce insulin resistance, it is recommended that dairy cows during the transition period be fed with monensin and propylene glycol supplements.
机译：在过渡期间，由于越来越多的胰岛素抵抗作为主要代谢干扰，乳制品奶牛受到负能量平衡。我们假设提供用于过渡乳制奶牛的葡萄糖前体可能降低胰岛素抵抗。在本研究中，在分娩前8周注册了24个多重荷斯坦奶牛，并分为4个相等的组，包括对照（CTRL），宫蛋白（MO），丙二醇（PPG）和MONENSIN加丙二醇（MO + PPG） 。来自MO和PPG组的奶牛每天接受Monensin的1mg / kg体重（BW）。来自PGG组的奶牛，每日收到150克丙二醇。来自Mo + PPG组的奶牛接受了1mg / kg宫蛋白的BW，每天150克/丙二醇头，Ctrl奶牛接受了没有任何补充的基础饮食。静脉内葡萄糖耐量试验（IVGTT）每周在分娩后3周前3周进行，以评估胰岛素抵抗现象。在葡萄糖给药后立即显着增加葡萄糖和胰岛素，在研究期间，它们的改变是显着的。 Ctrl组葡萄糖和胰岛素显着高于其他基团，在MO + PPG组中不同预先预先和产后期间的水平明显低于其他研究组。该研究的结果表明，与丙酸丁醇等丙酸丁醇和丙二醇等补充喂养，在过渡期间降低了乳制品奶牛的胰岛素抗性。这种效果比丙二醇更明显，而不是Monensin，并且两者的组合降低了较高速率的胰岛素抵抗力。这些膳食补充剂的使用可能会产生更多的丙酸盐作为葡萄糖的主要前体;因此，它降低了负能量平衡，随后降低胰岛素抵抗力。在这方面，为了降低胰岛素抵抗力，建议在过渡期间乳制品奶牛用宫素和丙二醇补充剂供给。

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