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首页> 外文期刊>Tropical Animal Health and Production >Suspected resistance of Trypanosoma species to diminazene aceturate on a cattle farm in Nigeria
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Suspected resistance of Trypanosoma species to diminazene aceturate on a cattle farm in Nigeria

机译：在尼日利亚的养牛场对睾丸瘤种类对二吡啶的抗性

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摘要

African animal trypanosomiasis is a major cause of mortality and economic losses for the livestock industry in Nigeria. Chemotherapy has been the most reliable option for cattle herders, and the most commonly found drug on the market is diminazene aceturate. To ascertain the long-term efficacy of this compound, we sampled a cattle herd in Ogun State, Nigeria, 2 months after they were treated with diminazene aceturate. The ITS-PCR results revealed 19 positives for trypanosome DNA out of the 79 samples tested (24.1%, 95% CI 16.0-34.5). Seventeen out of the total 19 positives were Trypanosoma congolense (21.5%, 95% CI 13.9-31.8). Mixed infections were also observed. Therefore, the persistence of bovine trypanosomiasis at this Nigerian cattle farm despite treatment could be due to diminazene aceturate resistant trypanosomes being present in the herd.
机译：非洲动物锥虫病是尼日利亚畜牧业死亡率和经济损失的主要原因。 化疗是牛牧民最可靠的选择，最常见的市场上的药物是醋酸二溴嗪。 为了确定这种化合物的长期疗效，我们在尼日利亚的Ogun州的牛群中取样了牛群，2个月后用二咪嗪治疗。 其-PCR结果显示出79个样品中的锥虫组DNA的19个阳性（24.1％，95％CI 16.0-34.5）。 总计19个阳性的17个是锥虫瘤（21.5％，95％CI 13.9-31.8）。 还观察到混合感染。 因此，尽管治疗的尼日利亚养牛场的牛锥虫病的持续存在可能是由于群体中存在的二嗪类醋酸二嗪抗性抗蛋白酶体。

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