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首页> 外文期刊>Tropical Animal Health and Production >NDV subgenotype VII(L) is currently circulating in commercial broiler farms of Iran, 2017-2018
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NDV subgenotype VII(L) is currently circulating in commercial broiler farms of Iran, 2017-2018

机译：NDV亚基试型VII（L）目前正在伊朗商业肉鸡农场循环，2017-2018

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Background Based on our previous work, it was discovered that some Newcastle disease virus (NDV) isolates from backyard poultry between 2011 and 2013 in Iran formed a new separate cluster when phylogenetic analysis based on the complete F gene sequence was carried out. The novel cluster was designated subgenotype VII(L) and published. Aim In the current study, for further validation, we initiated a comprehensive epidemiological study to identify the dominant NDV genotype(s) circulating within the country. Collection of samples was executed between October 2017 and February 2018 from 108 commercial broiler farms which reported clinical signs of respiratory disease in their broilers. Result We report that 38 of the farms (> 35%) tested positive for NDV. The complete F' gene sequences of seven of the isolates are shown as representative sequences in this study. According to the phylogenetic tree constructed, the recent broiler farm isolates clustered into the newly designated cluster Vll(L) together with the older Iranian backyard poultry isolates in our previous work. All the sequences shared the same virulence -associated F cleavage site of i12RRQKRI F 117. Conclusion Our phylogenetic analysis suggested that the NDV subgenotype VII(L) may have been derived from subgenotype VIld, and contrary to popular belief, subgenotype 'I1d may not be the dominant subgenotype in Iran. Tracking of the subgenotype on BLAST suggested that the NDV subgenotype V1I(L), although previously unidentified, may have been circulating in this region as an endemic virus for at least a decade. Other NDV genotypes, however, have also been reported in Iran in recent years. Hence, ongoing study is aimed at determining the exact dominant NDV genotypes and subgenotypes in the country. This will be crucial in effective mitigation of outbreaks in Iranian broiler farms.
机译：背景技术基于我们以前的工作，发现一些新的2011年和2013年在伊朗之间的后院疾病病毒（NDV）分离株在基于完整F基因序列的系统发育分析时形成了一个新的单独的群集。新型群集被指定为亚替型VII（L）并发布。目前在目前的研究中，为了进一步验证，我们启动了一个综合流行病学研究，以确定国家内循环的显性NDV基因型。样本的集合是在2017年10月和2018年2月之间执行的108个商业肉鸡农场，报告了肉鸡呼吸道疾病的临床症状。结果我们报告了38个农场（> 35％）测试了NDV的阳性。七个分离株的完整F'基因序列被示为本研究中的代表性序列。根据构建的系统发育树，最近的肉鸡农场与我们以前的工作中的较旧的伊朗后院家禽隔离物集聚到新指定的集群VLL（L）中。所有序列都分享了与I12RRQKRI F 117的相同毒力 - 分配的F切割位点。结论我们的系统发育分析表明，NDV亚型型VII（L）可能是衍生自亚磷酸型VID，并且与普遍的信念相反，亚型型'I1D可能不是伊朗的显性亚类型。追踪爆炸蛋白型的跟踪表明，NDV亚型型V1i（L）虽然先前未识别，但在该地区可能已经在该地区循环至少十年。然而，近年来，其他NDV基因型也在伊朗报道。因此，正在进行的研究旨在确定该国确切的占优势NDV基因型和亚因素。这将是有效缓解伊朗肉鸡农场的爆发。

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