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首页> 外文期刊>Tropical Animal Health and Production >Comparative aspects of immunity and vaccination in human and bovine trichomoniasis: a review
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Comparative aspects of immunity and vaccination in human and bovine trichomoniasis: a review

机译：人和牛滴虫中免疫和疫苗接种的比较方面：综述

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摘要

Trichomonas vaginalis and Tritrichomonas foetus are important extracellular protozoans that cause, respectively, human and bovine venereal diseases. Trichomonads are extracellular parasites that primarily inhabit the genital tracts of the mammalian hosts where they overcome the mucus barrier and parasitize mucosa by contact-dependent or contact-independent cytotoxicity. Transient immunity is usually achieved by the host after clinical infection. At present, vaccination in cattle reduces infection rates and reproductive wastage in affected herds. After vaccination, immunoglobulin G (IgG) levels increase in systemic circulation while immunoglobulin A (IgA) levels rise in the vagina. Only moderate protection is conferred by means of vaccination. Future vaccine development strategies are needed for cattle to enhance the antigenic component or use adjuvant that strongly activates the innate immune response to produce safe and potent vaccines. This paper reviews the current knowledge of the immunology of trichomoniasis infection and the challenges and potential of vaccines in the control of the infection in human and bovine trichomoniasis.
机译：毛耳菌和胎儿和三硝基莫氏菌是重要的细胞外原生动物，其分别引起人和牛性病疾病。 Trichomonads是细胞外寄生虫，主要居住在哺乳动物宿主的生殖器皿中，它们克服了粘液屏障，并通过接触依赖性或与接触的细胞毒性寄生粘膜。临床感染后，宿主通常通过宿主实现瞬时免疫。目前，牛的疫苗接种可降低受影响群体的感染率和生殖浪费。疫苗接种后，免疫球蛋白G（IgG）水平的全身循环增加，而免疫球蛋白A（IgA）水平升高了阴道。只有疫苗接种才能赋予中等保护。未来的疫苗开发策略对于牛来增强抗原组分或使用佐剂，强烈激活先天免疫应答，以产生安全和有效的疫苗。本文审查目前对滴虫病感染的免疫学的知识以及疫苗控制人类和牛滴毛病中感染的挑战和潜力。

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