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首页> 外文期刊>Tropical Animal Health and Production >Identification of candidate genes for paratuberculosis resistance in the native Italian Garfagnina goat breed
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Identification of candidate genes for paratuberculosis resistance in the native Italian Garfagnina goat breed

机译：鉴定意大利Garfagnina Goat品种原生意大利Garfagnina植物抗毛细血管抗性的候选基因

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摘要

Paratuberculosis disease is a chronic bacterial disease infection of ruminants of global relevance, caused by MAP (Mycobacterium avium subsp. paratuberculosis). The present study was conducted on the Garfagnina goat breed that is an Italian native goat population registered on the Tuscan regional repertory of genetic resources at risk of extinction. Forty-eight adult goats (27 serologically positive to MAP-positive and 21 serologically negative to MAP-negative) belonging to a single flock that had experienced annual mortalities due to MAP infection were identified and genotyped with the Illumina GoatSNP60 BeadChip. Diagnosis was achieved by serological tests, as well as post-mortem examination of affected animals. A genome-wide scan was then performed on the individual marker genotypes, in an attempt to identify genomic regions associated with MAP infection disease. Nine significant markers were highlighted and they were located within, or nearby, annotated genes. Two genes found in this study encode are linked to protein kinases that are among the most important enzymes involved in the immune response to Johne's disease, and four genes are involved in the functions of the Golgi complex.
机译：Paratuberculosis疾病是一种慢性细菌疾病，对反刍动物的反刍动物，由地图引起（分枝杆菌亚副分枝杆菌。伞菌癌）。本研究是在Garfagnina Goat品种上进行的，这是一种意大利天然山羊，在灭绝风险的遗传资源遗传资源上注册的意大利天然山羊。鉴定了属于由于地图感染导致的单个植物的单个群体的四十八个成年山羊（27型晶态阳性和21种血晶阴性），并用Illumina Goatsnp60珠芯片鉴定并基因分型。通过血清学检测实现诊断，以及对受影响动物的验尸检查。然后对个体标记基因型进行基因组扫描，以试图鉴定与地图感染疾病相关的基因组区域。突出9个重要标记，它们位于附近的注释基因内。本研究编码中发现的两种基因与蛋白激酶有关，该蛋白激酶是参与约翰疾病的免疫应答的最重要酶之一，并且四种基因参与了Golgi复合物的功能。

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