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首页> 外文期刊>Tropical Animal Health and Production >Prognostic value of serum potassium level predicting the duration of recumbency in downer cows due to metabolic disorders
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Prognostic value of serum potassium level predicting the duration of recumbency in downer cows due to metabolic disorders

机译：血清钾水平预测较代谢疾病持续卷发持续时间的预后价值

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摘要

Downer cows and variations in the treatment response are of great interest to farmers. Positively responded animals get up at different extended periods after receiving the same treatment protocol. The objective of this study is to determine if there is any association between the duration of recumbency and the level of serum biomarkers. Serum samples from 165 crossbred Holstein dairy cows (105 downer cows of metabolic causes only and 50 healthy) and from 65 cured cows after treatment were used for analysis of calcium (Ca), inorganic phosphorus (P), potassium (K), magnesium (Mg), creatine phosphokinase (CPK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), beta-hydroxybutyric acid (BHBA), non-esterified fatty acid (NEFA), and triglycerides (TG). Assessment of diagnostic performance of these biomarkers was performed using analysis of the receiver operating characteristic (ROC). Serum levels of Ca, P, K, and TG decreased significantly (P < 0.001), while CPK, AST, ALT, BHBA, and NEFA increased significantly (P < 0.001) in those downers compared with controls. They achieved high diagnostic performance in ROC curve analysis. Interestingly, 65 cows responded after treatment and stood up (cured cases) after a period of recumbency varying from 4 to 15 days and statistics revealed a significant association (P < 0.05) between those days of recumbency and only serum K levels. We concluded that only the serum potassium (K) level is a significant predictor of post-treatment recumbency period and that the serum P, CPK, and NEFA levels have the highest diagnostic performance.
机译：越来越多的奶牛和治疗反应的变化对农民具有很大兴趣。在收到相同的治疗方案后，积极响应的动物在不同的延长时期起床。本研究的目的是确定闭合之间存在持续时间和血清生物标志物的水平之间是否存在任何关联。血清样本来自165克罗斯富尔斯坦奶牛（仅在治疗后的105岁的代谢原因和50奶牛）和65奶牛的治疗后，用于分析钙（CA），无机磷（P），钾（K），镁（ Mg），肌酸磷酸氨基酶（CPK），天冬氨酸氨基转移酶（AST），丙氨酸氨基转移酶（ALT），γ-戊酰基转移酶（GGT），β-羟基丁酸（BHBA），非酯化脂肪酸（NEFA）和甘油三酯（TG ）。使用接收器操作特征（ROC）进行这些生物标志物的诊断性能评估。血清Ca，p，k和Tg水平显着下降（p <0.001），而CPK，AST，ALT，BHBA和NEFA在那些与对照相比这些较低的越来越大（P <0.001）。他们在ROC曲线分析中实现了高诊断性能。有趣的是，在治疗后65次母牛答复并站起来（治愈案例）后，在4至15天的闭合时间变化后，统计数据透露了闭密性和血清K水平之间的重要关联（P <0.05）。我们得出结论，只有血清钾（K）水平是治疗后闭合时间的显着预测因子，并且血清P，CPK和Nefa水平具有最高的诊断性能。

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