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首页> 外文期刊>Trends in Neurosciences >A Bundle of Mechanisms: Inner-Ear Hair-Cell Mechanotransduction
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A Bundle of Mechanisms: Inner-Ear Hair-Cell Mechanotransduction

机译:一束机制:内耳毛细胞机械调节

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摘要

In the inner ear, the deflection of hair bundles, the sensory organelles of hair cells, activates mechanically-gated channels (MGCs). Hair bundles monitor orientation of the head, its angular and linear acceleration, and detect sound. Force applied to MGCs is shaped by intrinsic hair-bundle properties, by the mechanical load on the bundle, and by the filter imparted by the environment of the hair bundle. Channel gating and adaptation, the ability of the bundle to reset its operating point, contribute to hair-bundle mechanics. Recent data from mammalian hair cells challenge longstanding hypotheses regarding adaptation mechanisms and hair-bundle coherence. Variations between hair bundles from different organs in hair-bundle mechanics, mechanical load, channel gating, and adaptation may allow a hair bundle to selectively respond to specific sensory stimuli.
机译:在内耳中,毛束的偏转,毛细胞的感觉细胞器,激活机械门控通道(MGC)。 头发捆绑头部的定向,其角度和线性加速度,并检测声音。 施加到MGCs的力由本型发束性能,通过束的机械负载以及由头发束的环境赋予的过滤器。 通道门控和适应,捆绑重置其操作点的能力有助于发束力学。 来自哺乳动物毛发细胞的最近数据挑战了关于适应机制和毛发连贯性的长期假设。 毛束力学,机械负载,通道门控和适应不同器官的毛发束之间的变化可以允许头发束选择性地响应特定的感觉刺激。

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