The Brain Is Needed to Cure Spinal Cord Injury

Isa Tadashi

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The Brain Is Needed to Cure Spinal Cord Injury

机译：需要治疗脊髓损伤的大脑

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Damage to corticospinal fibers in the cervical spinal cord is known to impair dexterous hand movements. However, accumulating evidence has shown that precision grip can recover considerably through rehabilitative training. Recent multidisciplinary studies have revealed that, at the spinal level, this recovery is possible due to an indirect neural pathway through propriospinal neurons (PNs), which relay cortical commands to hand motoneurons. Although this indirect spinal pathway is heavily involved in recovery, its role is dwarfed by a simultaneous large-scale network reorganization spanning motor-related cortices and mesolimbic structures. This large-scale network reorganization is key to the regulation of recovery and future therapeutic strategies will need to take into account the involvement of these supraspinal centers in addition to the known role of the spinal cord.

机译：已知宫颈脊髓中皮质纤维的损伤是损害灵巧的手动运动。然而，积累的证据表明，精密握把可以通过康复培训大大恢复。最近的多学科研究表明，在脊柱水平时，由于通过血管神经元（PNS）的间接神经途径，这种恢复是可能的，这将皮质命令用于手动运动神经元。虽然这种间接脊柱途径严重涉及恢复，但其作用是通过同时大规模网络重组跨越电动机相关的皮质和培养基结构的作用。这种大规模的网络重组是恢复监管的关键，未来的治疗策略将需要考虑到这些脊柱脊髓的已知作用外的这些袋子中心的参与。

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来源
《Trends in Neurosciences》 |2017年第10期|共12页
作者
Isa Tadashi;
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作者单位

Kyoto Univ Grad Sch Med Dept Neurosci Kyoto 6068501 Japan;

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正文语种 eng
中图分类神经病学;
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1. Contusive spinal cord injury up regulates mu-opioid receptor (mor) gene expression in the brain and down regulates its expression in the spinal cord: possible implications in spinal cord injury research [J] . Michael Felicia Mary, Mohapatra Alok Nath, Venkitasamy Lavanya, Neurological Research: An Interdisciplinary Quarterly Journal . 2015,第9期

机译：挫伤性脊髓损伤可上调大脑中的阿片受体（mor）基因表达，下调其在脊髓中的表达：可能对脊髓损伤研究产生影响
2. International Campaign for Cures of Spinal Cord Injury Paralysis (ICCP): another step forward for spinal cord injury research. [J] . Adams M, Cavanagh JF Spinal cord: the official journal of the International Medical Society of Paraplegia . 2004,第5期

机译：国际脊髓损伤麻痹治疗运动（ICCP）：脊髓损伤研究又向前迈进了一步。
3. Brain derived neurotrophic factor and trk B mRNA expression in the brain of a brain stem-spinal cord regenerating model, the European eel, after spinal cord injury. [J] . Dalton VS, Roberts BL, Borich SM Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2009,第3期

机译：脊髓损伤后脑干-脊髓再生模型欧洲鳗鱼的脑源性神经营养因子和trk B mRNA表达。
4. Towards a miniaturized brain-machine-spinal cord interface (BMSI) for restoration of function after spinal cord injury [C] . Shahdoost Shahab, Frost Shawn, Van Acker Gustaf, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2014

机译：迈向小型化的脑机-脊髓接口（BMSI）以恢复脊髓损伤后的功能
5. Theoretical and experimental evaluation of a simple cooling pad for inducing hypothermia in the brain and in the spinal cord following traumatic spinal cord injury. [D] . Smith, Katisha Devon. 2010

机译：理论和实验评估一个简单的冷却垫，用于在创伤性脊髓损伤后在大脑和脊髓中诱导体温过低。
6. Neurophysiological Changes After Paired Brain and Spinal Cord Stimulation Coupled With Locomotor Training in Human Spinal Cord Injury [O] . Timothy S. Pulverenti, Morad Zaaya, Monika Grabowski, 2021

机译：与人脊髓损伤的运动训练结合后的脑和脊髓刺激后神经生理学变化
7. Position statement on the sale of unproven cellular therapies for spinal cord injury The International Campaign for Cures of Spinal Cord Injury Paralysis [O] . Blight, A, Curt, A, Ditunno, J F, 2009

机译：关于出售未经证实的脊髓损伤细胞疗法的立场声明国际脊髓损伤麻痹治疗运动
8. Reversing Maladaptive Plasticity to Cure Autonomic Dysreflexia after Spinal Cord Injury. [R] . Popovich, P., Wang, Y., Guan, Z., 2016

机译：逆转适应不良可塑性以治疗脊髓损伤后的自主神经反射不良。

The Brain Is Needed to Cure Spinal Cord Injury

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