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首页> 外文期刊>Neurological Research: An Interdisciplinary Quarterly Journal >Contusive spinal cord injury up regulates mu-opioid receptor (mor) gene expression in the brain and down regulates its expression in the spinal cord: possible implications in spinal cord injury research
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Contusive spinal cord injury up regulates mu-opioid receptor (mor) gene expression in the brain and down regulates its expression in the spinal cord: possible implications in spinal cord injury research

机译：挫伤性脊髓损伤可上调大脑中的阿片受体（mor）基因表达，下调其在脊髓中的表达：可能对脊髓损伤研究产生影响

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Traumatic spinal cord injury (SCI) is one of the dreaded neurological conditions and finding a cure for it has been a hot area of research. Naloxone - a mu-opiate receptor (mor) antagonist was considered for SCI treatment based on its positive effects under shock conditions. In contrary to animal studies based reports about the potential benefits of naloxone in treating SCI, a large scale clinical trial [National Acute Spinal Cord Injury Study II (NASCIS II)] conducted in USA failed to witness any effectiveness. The inconsistency noticed was intriguing. Therefore, the objective of the present study was to re-examine the role of naloxone in treating SCI using a highly standardised Multicenter Animal Spinal Cord Injury Study (MASCIS) animal model of contusive SCI. Results indicated that naloxone produced negligible and insignificant neuroprotection. In an attempt to understand the cause for the failure, it was found that mu-opioid receptor (mor) gene expression was upregulated in the brain but was down regulated in the spinal cord after contusive SCI. Given that the beneficial effects of naloxone are through its action on the mor, the results indicate that unlike the brain, spinal cord might not be bracing to utilise the opiate system in the repair process. This could possibly explain the failure of naloxone treatment in NASCIS II. To conclude, opiate antagonists like naloxone may be neuroprotective for treating traumatic brain injuries, but not for traumatic/contusive spinal cord injuries.
机译：创伤性脊髓损伤（SCI）是令人恐惧的神经系统疾病之一，找到治疗方法已成为研究的热点。纳洛酮-一种多阿片受体（mor）拮抗剂被认为可用于SCI治疗，因为它在休克条件下具有积极作用。与基于动物研究的有关纳洛酮治疗SCI潜在益处的报道相反，在美国进行的一项大规模临床试验[美国国家急性脊髓损伤研究II（NASCIS II）]未能见效。所发现的不一致之处很有趣。因此，本研究的目的是使用高度标准化的挫伤性SCI动物多中心动物脊髓损伤研究（MASCIS）动物模型，重新检查纳洛酮在治疗SCI中的作用。结果表明，纳洛酮对神经的保护作用微不足道。为了了解失败的原因，发现挫伤性脊髓损伤后，μ阿片受体（mor）基因表达在大脑中被上调，但在脊髓中被下调。鉴于纳洛酮的有益作用是通过其对mor的作用，结果表明，与大脑不同，脊髓可能不准备在修复过程中利用鸦片系统。这可能可以解释NASCIS II中纳洛酮治疗的失败。总而言之，鸦片拮抗剂（如纳洛酮）可能在治疗颅脑外伤方面具有神经保护作用，但对于创伤/挫伤性脊髓损伤却不具有神经保护作用。

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