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首页> 外文期刊>Veterinary and Comparative Oncology >Evaluation of a 0.75 x 10(9)/L absolute neutrophil count cut-off for antimicrobial prophylaxis in canine cancer chemotherapy patients
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Evaluation of a 0.75 x 10(9)/L absolute neutrophil count cut-off for antimicrobial prophylaxis in canine cancer chemotherapy patients

机译：评价犬癌癌化疗患者抗菌预防的0.75×10（9）/ L绝对中性粒细胞计数截止

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Absolute neutrophil count (ANC) cut-offs for antimicrobial prophylaxis in veterinary cancer chemotherapy patients are empirical and vary between institutions. Evidence based cut-offs are vital for antimicrobial stewardship, particularly as global antimicrobial resistance rises. The primary objectives of this study were to evaluate the tolerability of a <0.75 x 10(9)/l ANC cut-off for antimicrobial prophylaxis in dogs after receiving chemotherapy and its impact on antimicrobial prescription. Predicted nadir ANCs (pnANCs) were stratified into six groups (<0.75 x 10(9)/l [receiving antimicrobial prophylaxis], 0.75-0.99 x 10(9)/l, 1-1.49 x 10(9)/l, 1.5-1.99 x 10(9)/l, 2.0-3.59 x 10(9)/l and 3.6-12 x 10(9)/l [reference interval]). The incidences of post-nadir febrile neutropenia (FN) and non-haematological toxicity (NHT) were compared between groups. Five hundred and eighty-six pnANCs were recorded for 181 dogs. There were four episodes of post-nadir FN and 90 episodes of post-nadir NHT. There was no significant difference in incidence of post-nadir FN (P = .063) or post-nadir NHT (P = .084) between pnANC groups. Antimicrobial prophylaxis was prescribed following 8.8% of the chemotherapy administrations; had cut-off values of <1.0 x 10(9)/l or <1.5 x 10(9)/l been used it would have been prescribed in 15.3% and 25.8% of cases respectively. An ANC cut-off of <0.75 x 10(9)/l for antimicrobial prophylaxis appears to be well tolerated and minimizes the prescription of antimicrobials.
机译：兽医癌化疗患者抗菌预防患者的绝对中性粒细胞计数（ANC）截止症是在机构之间的经验和各种各样的各种各样。基于证据的截止对于抗微生物管道至关重要，特别是随着全球抗微生物抗性升高。本研究的主要目标是评估接受化疗后犬抗菌预防的<0.75×10（9）/ l ANC截止的可耐受性及其对抗菌处方的影响。将预测的Nadir ANC（PNANC）分为六组（<0.75×10（9）/ L [接收抗微生物预防]，0.75-0.99×10（9）/ L，1-1.49×10（9）/ L，1.5 -1.99 x 10（9）/ l，2.0-3.59 x 10（9）/ l和3.6-12 x 10（9）/ l [参考间隔]）。在组之间比较了Nadir发热中性蛋白（Fn）和非血液学毒性（NHT）的发生率。为181只狗记录了五百八十六个普氏粉末。 Nadir的后Nadir Fn和90个发作的后Nadir NHT发作。在PNANC组之间的NADIR FN（p = .063）或Nadir nadir（p = .084）的发生率没有显着差异。在化疗施用8.8％以下的8.8％以下规定抗菌预防;截止值<1.0×10（9）/ L或<1.5×10（9）/ l已被使用，分别在15.3％和25.8％的病例中规定。对于抗微生物预防的<0.75×10（9）/ L的ANC截止似乎是良好的耐受性并最小化抗微生物的处方。

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