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首页> 外文期刊>Vascular and endovascular surgery >A Systematic Review of the Use of Biochemical Markers in the Assessment of Spinal Cord Ischemia in Thoracoabdominal Aortic Aneurysm Repair
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A Systematic Review of the Use of Biochemical Markers in the Assessment of Spinal Cord Ischemia in Thoracoabdominal Aortic Aneurysm Repair

机译：生化标志物在胸腹主动脉动脉瘤修复中脊髓缺血评估中使用生化标志物的系统综述

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Introduction: Despite advances in perioperative critical care and surgical technique, spinal cord ischemia remains a devastating complication of thoracic and thoracoabdominal aortic aneurysm repair. Biochemical markers present in peripheral blood and cerebrospinal fluid (CSF) may be useful in assessing spinal cord injury. We systematically analyze and report the role of all reported biochemical markers that have been used in assessing and diagnosing spinal cord ischemia in thoracic and thoracoabdominal aortic aneurysm repair. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were used for this review. Published literature was searched to identify all studies reporting on the use of biochemical markers in thoracoabdominal aortic aneurysm repair in the assessment of spinal cord ischemia. Marker-specific and patient-specific data were extracted from all studies and where possible, subgroup analysis was performed on marker-specific data sets. Results: Fourteen studies of 321 patients undergoing thoracic and thoracoabdominal aortic aneurysm repair were eligible for further analysis. Seven distinct biochemical markers were used in both CSF and blood samples: S100B proteins (S100B), neurone-specific enolase, lactate dehydrogenase, glial fibrillary acidic protein (GFAp), neurofilament triplet protein (NFL) and Tau protein, and glucose. There was substantial evidence demonstrating the heightened levels of S100, NFL, and GFAp in CSF in patients with spinal cord ischemia. There is however, wide variability in the correlation of the same 6 biochemical markers in peripheral blood and spinal cord ischemia. Conclusions: In patients with spinal cord injury, dramatic rises occur with S100B, NFL, and GFAp in CSF. However, further work is needed if biochemical markers are to impact on the future of thoracoabdominal aortic aneurysm repair.
机译：介绍：尽管围手术期关键护理和外科手术技术进展，但脊髓缺血仍然是胸腔和胸腹主动脉瘤修复的破坏性并发症。外周血和脑脊液（CSF）中存在的生化标志物可用于评估脊髓损伤。我们系统地分析和报告所有报告的生化标志物中已被用于评估和诊断脊髓缺血在胸腔和胸腔腹主动脉瘤修复中的作用。方法：用于系统评价的首选报告项目和荟萃分析指南的审查。搜查了出版的文献，以确定关于在脊髓缺血评估中胸腔系主动脉瘤修复中使用生化标志物的所有研究报告。从所有研究中提取标记特异性和患者特异性数据，从而在可能的情况下，对标记特定数据集进行亚组分析。结果：321例接受胸腔和胸腹主动脉瘤修复的321名患者的研究有资格进行进一步分析。七种不同的生物化学标记用于CSF和血液样品：S100B蛋白（S100B），神经元特异性烯醇酶，乳酸脱氢酶，胶质纤维酸性蛋白（GFAP），神经丝三重蛋白（NFL）和TAU蛋白，以及葡萄糖。有很大的证据证明脊髓缺血患者CSF中的S100，NFL和GFAP水平的高度。然而，在外周血和脊髓缺血中相同的6种生物化学标志物的相关性具有广泛的变化。结论：在脊髓损伤的患者中，CSF中的S100B，NFL和GFAP发生显着升高。然而，如果生物化学标记对胸腹主动脉瘤修复的未来影响，则需要进一步的工作。

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