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首页> 外文期刊>Vector borne and zoonotic diseases >A Tale of Two Valleys: Disparity in Sin Nombre Virus Antibody Reactivity Between Neighboring Mojave Desert Communities
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A Tale of Two Valleys: Disparity in Sin Nombre Virus Antibody Reactivity Between Neighboring Mojave Desert Communities

机译：两只谷的故事：邻近莫哈韦沙漠社区之间的罪恶中的罪恶病毒抗体反应性

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Introduction: Hantaviruses are a group of globally distributed rodent-associated viruses, some of which are responsible for human morbidity and mortality. Sin Nombre orthohantavirus, a particularly virulent species of hantavirus associated with Peromyscus spp. mice, is actively monitored by the Department of Public Health in California (CDPH). Recently, CDPH documented high (40%) seroprevalence in a potentially novel reservoir species, the cactus mouse (Peromyscus eremicus) in Death Valley National Park. Methods: This study was performed in the extremely isolated Mojave Desert Amargosa River valley region of southeastern Inyo County, California, 105 km from Death Valley, approximately over the same time interval as the CDPH work in Death Valley (between 2011 and 2016). Similar rodent species were captured as in Death Valley and were tested for select hantaviruses using serology and RT-PCR to assess risk to human health and the conservation of the endemic endangered Amargosa vole. Results: Among 192 rodents tested, including 56 Peromyscus spp., only one seropositive harvest mouse (Reithrodontomys megalotis) was detected. Discussion: These data highlight the heterogeneity in the prevalence of hantavirus infection even among nearby desert communities and suggest that further studies of hantavirus persistence in desert environments are needed to more accurately inform the risks to public health and wildlife conservation.
机译：简介：HantaViruses是一组全球分布的啮齿动物相关病毒，其中一些是人类发病率和死亡率的原因。 Sin Nombre orthantavirus，一种与Peromyscus SPP相关的特别毒性的汉坦病毒。在加利福尼亚州（CDPH）的公共卫生部主动监测小鼠。最近，CDPH以潜在的新储层物种，仙人掌小鼠（Peromyscus erexicus）在死亡谷国家公园中记录了高（40％）的血清透析。方法：本研究在加利福尼亚州东南部的东南部的Mojave沙漠Amargosa河谷地区进行了105公里，大约在与死亡谷的CDPH工作（2011年和2016年间）相同的时间间隔。类似的啮齿动物物种被捕获为死亡谷，并使用血清学和RT-PCR选择汉坦病毒，以评估人类健康的风险，并保护人流域濒临灭绝的amargosa vole。结果：在测试的192个啮齿动物中，包括56个细胞瘤SPP。，只检测到一个血清阳性鼠尾（Reithrodontomys Megalotis）。讨论：这些数据甚至在附近的沙漠社区中突出了Hantavirus感染患病率的异质性，并表明需要在沙漠环境中进一步研究汉坦病毒持久性，以便更准确地向公共卫生和野生动物保护提供风险。

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