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首页> 外文期刊>Twin research and human genetics : >Genetic Influences on Evening Preference Overlap with Those for Bipolar Disorder in a Sample of Mexican Americans and American Indians
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Genetic Influences on Evening Preference Overlap with Those for Bipolar Disorder in a Sample of Mexican Americans and American Indians

机译：在墨西哥人和美洲印第安人样本中，晚间偏好的遗传影响与双相障碍重叠

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Diurnal preference (e.g., being an owl or lark) has been associated with several psychiatric disorders including bipolar disorder (BP), major depressive disorder, and substance use disorders. Previous large-scale genome-wide association studies (GWAS) aimed at identifying genetic influences on diurnal preference have exclusively included subjects of European ancestry. This study examined the genetic architecture of diurnal preference in two minority samples: a young adult sample of Mexican Americans (MAs), and a family-based sample of American Indians (AIs). Typed or imputed variants from exome chip data from the MA sample and low pass whole-genome sequencing from the AI cohort were analyzed using a mixed linear model approach for association with being an owl, as defined by a usual bedtime after 23:00 hrs. Genetic risk score (GRS) profiling detected shared genetic risk between evening preference and related disorders. Four variants in KIAA1549 like (KIAA1549L), a gene previously associated with attempted suicide in bipolar patients, were suggestively associated with being an owl at p < 1.82E-05; post hoc analyses showed the top variant trending in both the MA and AI cohorts at p = 2.50E-05 and p = .030, respectively. Variants associated with BP at p < .03 from the Psychiatric Genomics Consortium nominally predicted being an owl in the MA/AI cohort at p = .012. This study provides some additional evidence that genetic risk factors for BP also confer risk for being an owl in MAs/AIs and that evening preference may be a useful endophenotype for future studies of BP.
机译：昼夜偏好（例如，猫头鹰或百灵鸟）已与多种精神病疾病有关，包括双相障碍（BP），重大抑郁症和物质使用障碍。以前的大规模基因组 - 范围协会研究（GWAs）旨在识别关于昼夜偏好的遗传影响仅包括欧洲血统的主题。本研究审查了两种少数民族样本中的昼夜偏好的遗传建筑：墨西哥裔美国人（MAS）的年轻成人样本，以及一家以家庭为基础的美国印第安人样本（AIS）。使用混合线性模型方法分析来自MA样品的exome芯片数据的类型或避税变体，从AI队列中，使用混合的线性模型方法来与猫头鹰相关联，如23:00后的通常睡前所定义。遗传风险评分（GRS）剖析检测到晚间偏好和相关疾病之间的共同遗传风险。 KiaA1549的四种变体如（KIAA1549L），先前与双极患者试图自杀相关的基因，暗示与P <1.82E-05的猫头鹰有关;后HOC分析显示P = 2.50e-05和P = .030的MA和AI队列中的顶部变体趋势。来自PS P <0.03的BP相关的变体来自精神科学基因组学联盟，名义上预测在P = .012的MA / AI队列中的猫头鹰。本研究提供了一些额外的证据，即BP的遗传危险因素也会赋予MAS / AIS中猫头鹰的风险，并且晚间偏好可能是未来对BP的研究的有用内型。

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