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首页> 外文期刊>Veterinary Ophthalmology >Impact of acute conjunctivitis on ocular surface homeostasis in dogs
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Impact of acute conjunctivitis on ocular surface homeostasis in dogs

机译：急性结膜炎对狗眼表面稳态的影响

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摘要

Objective To investigate the effects of acute conjunctivitis on tear film characteristics and corneal sensitivity in dogs. Animals studied Eight female spayed Beagle dogs (1.5-2 years old, 7.5-10 kg). Procedures On two consecutive days, one randomly selected eye in each dog received 1 or 375 mg/mL histamine solution to induce mild or severe conjunctivitis, while the contralateral eye served as control. Diagnostic tests were performed in the following order: fluorescein instillation and repeated tear collection over 20 minutes (to determine tear volume [TV] and turnover rate [TTR] by fluorophotometry), Schirmer tear test-1 (STT-1), tear ferning, corneal esthesiometry, and tear film breakup time (TFBUT). Results Results are presented as median values for severe conjunctivitis, mild conjunctivitis, and control eyes. Eyes with severe conjunctivitis had significantly higher STT-1 (24, 19.5, 17.5 mm/min;P = .002) and significantly lower TFBUT (10.5, 13.5, 15.5 s;P = .002), but no changes were noted in corneal tactile sensation (2, 2.5, 2.5 cm) or tear ferning (grades 2, 2, 2.5). Severe conjunctivitis significantly increased TV by nearly 10-fold (631, 97, 65 mu L) initially (reflex tearing), although basal TV returned rapidly (<5 minutes) in all eyes (46, 58, 48 mu L). Finally, there was a nonsignificant trend for higher reflex TTR in the conjunctivitis vs control eyes (68, 58, 43%/min). Conclusions Experimentally induced conjunctivitis increases tear quantity and decreases tear quality in dogs, but has no impact on corneal sensitivity. Changes in tear film dynamics could affect ocular pharmacology (eg, precorneal retention time), although homeostasis of lacrimal volume and drainage is rapidly restored.
机译：目的探讨急性结膜炎对狗撕裂膜特征及角膜敏感性的影响。动物研究了八只女性飞狗狗（1.5-2岁，7.5-10千克）。步骤连续两天，每只狗随机选择的眼睛接受1或375mg / ml组胺溶液，以诱导轻度或严重的结膜炎，而对侧眼睛用作对照。诊断测试按以下顺序进行：荧光素滴注和重复的撕裂收集超过20分钟（通过荧光体测定撕裂液[TTR]和周转率[TTR]），Shirmer撕裂测试-1（STT-1），撕裂撕裂，角膜esthersiefortry和撕裂膜破碎时间（Tfbut）。结果结果呈现为严重结膜炎，轻度结膜炎和控制眼的中位数值。严重结膜炎的眼睛显着高于STT-1（24,19.5,17.5毫米/分钟; P = .002），显着降低TFBUT（10.5,13.5,15.5秒; P = .002），但在角膜中没有注意到变化触觉感觉（2,2，2.5,2.5cm）或撕裂渡口（2,2,2,2.5级）。严重的结膜炎最初（631,97,65 mu L）最初增加电视（反射撕裂），尽管所有眼睛（46,58,48μl）迅速返回（<5分钟）的基底电视。最后，在结膜炎的较高反射TTR中存在不显着的趋势，VS控制眼（68,58,43％/分钟）。结论实验诱导的结膜炎增加了泪水，减少了狗的泪液，但对角膜敏感性没有影响。撕裂膜动力学的变化可能影响眼科药理学（例如，预诊断时间），尽管泪腺量和排水的稳态迅速恢复。

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