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首页> 外文期刊>Veterinary Parasitology >A vaccination trial with a precocious line of Eimeria magna in Algerian local rabbits Oryctolagus cuniculus
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A vaccination trial with a precocious line of Eimeria magna in Algerian local rabbits Oryctolagus cuniculus

机译：在阿尔及利亚本地兔子的eimeria magna患有疫苗接种试验，在阿尔及利亚本地兔子或yctolagus cuniculus

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摘要

Coccidiosis is a major health problem in rabbits. A vaccine using Eimeria with perfect safety and effectiveness seems to be necessary to face this parasitosis. To assess the safety and the efficacy of a vaccine based on the Algerian precocious line of Eimeria magna against rabbit coccidiosis, twenty eight young rabbits from six litters of Coccidia free females were used to monitor oocystal excretion and body weights, they were distributed into four groups (vaccinated-challenged group, double challenged non vaccinated group, simple challenged non vaccinated group and control group). Three other Coccidia free rabbits served for the necropsy in order to compare the effect of the wild and the precocious strains of Eimeria magna at the histological level. Following the challenge inoculation, a statistically significant decrease of about 97% in the oocyst excretion was noticed in the vaccinated rabbits as a sign of a good immune response acquired by the vaccination associated to a good growth rate. Moreover, a statistically significant increase in oocyst output following the challenge in both double challenged non vaccinated group and simple challenged non vaccinated one was noticed: (1.2 x 10(8) and 1.5 x 10(8) vs 4.6 x 10(6) oocysts/rabbit respectively). Taking the control group showing a steady growth as a reference, the vaccinated rabbits showed a good growth during the experiment (p & 0.05). Globally the challenged groups showed a normal growth compared with the control group except for a temporary decrease in weights. No case of diarrhea was recorded in the vaccinated challenged group and the control one (neither vaccinated nor challenged) whereas more than 50% of the young rabbits from both simple and double challenged non vaccinated groups presented diarrhea. Consequently, the Algerian precocious strain of Eimeria magna constitute a good candidate for anticoccidian vaccine in the future.
机译：球虫病是兔子的主要健康问题。使用具有完美安全性和有效性的疫苗似乎有必要面对这种寄生虫。为了评估基于患有兔敌人的艾米氏菌的疫苗疫苗的安全性和疗效，来自六个窝的六窝免费女性的二十八只幼鸽用于监测卵囊排泄和体重，它们分为四组（疫苗接种挑战群，双重挑战的非疫苗基团，简单挑战的非接种疫苗组和对照组）。其他三只可口可数兔子为尸检服务，以比较野生和早熟的eimeria magna的效果​​在组织学水平。在接种挑战之后，在接种兔中注意到卵囊排泄中约97％的统计学上显着降低，作为通过与良好生长速率相关的疫苗接种的良好免疫应答的迹象。此外，注意到双重攻击的非接种疫苗基团挑战后卵囊输出的统计学上显着增加，并且有简单的挑战未疫苗的非接种疫苗的输出：（1.2×10（8）和1.5×10（8）与4.6 x 10（6）卵囊/兔子分别）。服用对照组显示稳定增长作为参考，疫苗接种的兔子在实验期间表现出良好的增长（P＆amp; 0.05）。除非重量暂时降低，全球挑战的群体与对照组相比显示了正常增长。疫苗的攻击组中没有记录腹泻的情况，对照组（既不接种疫苗或挑战），而从简单和双重挑战的非疫苗群体中超过50％的幼鸽患者呈现腹泻。因此，Eimeria Magna的阿尔及利亚早期菌株在未来构成了抗癌疫苗的良好候选者。

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