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Encephalitozoonosis infection in a traditional rabbit farm with neurological manifestations

机译：在传统兔子农场的脑肌肌酶症感染具有神经表现

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Encephalitozoon cuniculi, a zoonotic and opportunistic pathogen, can cause latent infection, especially in lagomorphs. Nowadays, this member of the Eukaryotes has drawn significant attention in the fields of veterinary and public health. The purpose of this study was to determine the seroprevalence of infection in a New Zealand rabbit farm that has a clinical history of neurological manifestations including head tilt ataxia, aggressiveness, seizures, and circling and rotational movements around the body length axis, but the general conditions and food intake were normal. Blood samples were taken from 42 breeding rabbits and researched for E. cuniculi anti-bodies. Out of that, 25 (59%) animals resulted positive against the pathogen. The rabbit was found to be sero-positive for E. cuniculi antibodies, but negative for Toxoplasma gondii and Listeria monocytogenes antibodies. Hematological and serum biochemical parameters were measured at reference intervals. No brain tissue impairment was observed the computed tomography (CT) scan. As a result of these histopathological findings, the brain cortex presented severe neuronal degeneration and partial myelin loss, with reactive diffuse gliosis against the parasite spores was observed to the histopathology. These results are possibly related to the early stage of infection because the parasitic infestation comprise long time spreading. E. cuniculi DNA was detected on brain tissues using polymerase chain reaction (PCR), and it partial DNA sequence was identified as E. cuniculi genotype I.
机译：脑梗死丘西锡，一种人群和机会主义病原体，可能导致潜伏感染，尤其是在Lagomorphs中。如今，这家真核生物成员在兽医和公共卫生领域引起了重大关注。本研究的目的是确定新西兰兔农场感染的血清伪装，其具有神经表现的临床史，包括头部倾斜，侵蚀性，癫痫发作和体长轴周围的侵蚀和旋转运动，但是一般情况食物摄入量正常。血液样品从42只育种兔取出，并研究了E. Cuniculi抗体。出了25（59％）动物导致病原体阳性。发现兔子对E. Cuniculi抗体的血清阳性，但对于弓形虫和Histeria单核细胞生成的抗体负阴性。以参考间隔测量血液学和血清生物化学参数。没有观察到脑组织损伤的计算机断层扫描（CT）扫描。由于这些组织病理学发现，脑皮质呈现严重的神经元变性和部分髓鞘损失，并且对组织病理学观察到对寄生虫孢子的反应性漫射渗透率。这些结果可能与感染的早期阶段有关，因为寄生虫灭绝包括长时间的蔓延。 E.使用聚合酶链式反应（PCR）在脑组织上检测到Cuniculi DNA，并将其部分DNA序列鉴定为E. cuniculi基因型I.

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