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Inter- and Intraobserver Agreement of Canine and Feline Nervous System Tumors

机译：犬和猫科动物神经系统肿瘤的间交际协议

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In routine diagnostic activity, pathologists may be confronted with nervous system tumors. The lack of clinical information, economic restrictions for additional testing, and the lack of expertise in neuropathology may render the diagnosis challenging. The goals of this study were to assess the agreement in diagnosing nervous system tumors in domestic carnivores among 4 board-certified surgical pathologists without particular expertise in neuropathology and a neuropathologist expert, and to investigate the utility of special stains frequently used in routine diagnostic laboratories. Forty-six tumors (7 cats, 38 dogs, and 1 unknown carnivore) were retrieved and 1 hematoxylin and eosin-stained slide per tumor was selected. Diagnoses (tumor type and subtype) were formulated based on histological features and available clinical information. Confidence in the diagnosis was also scored. Subsequently, a panel of histochemical and immunohistochemical stains (Gordon Sweet silver stain and immunohistochemistry for AE1/AE3, vimentin, glial fibrillary acid protein, S100, neuron-specific enolase and neurofilament) was evaluated by the pathologists, who either confirmed or changed their original diagnoses. Intraobserver and interobserver agreement and confidence in relation to diagnosis before and after analysis of special stains were assessed. The use of special stains increased the complete agreement among surgical pathologists, with regard to tumor type, from 63% to 74%. Cases with a high confidence score had a higher interobserver agreement than cases with a low confidence score. These results suggest that pathologists without expertise in neuropathology agree in the diagnosis of most nervous system tumors, and special stains available in most laboratories only slightly increase this agreement.
机译：在常规诊断活动中，病理学家可能面临着神经系统肿瘤。缺乏临床信息，对额外测试的经济限制以及神经病理学缺乏专业知识可能会使诊断具有挑战性。本研究的目标是评估4个董事会认证的外科病理学家在没有特定专业的神经病理学和神经病理学家专家的诊断中诊断神经系统肿瘤的协议，并调查常规诊断实验室经常使用的特殊污渍的效用。检测到四十六种肿瘤（7只猫，38只狗和1个未知的肉食病程），选择每次肿瘤的1个苏木精和嗜酸盐染色的载玻片。基于组织学特征和可用的临床信息，配制诊断（肿瘤类型和亚型）。还得分对诊断的信心。随后，通过病理学家评估了组织化学和免疫组织化学污渍（Gordon甜银染色和AE1 / AE3，Vimentin，胶质纤维酸蛋白，S100，神经元特异性烯醇酶和神经覆膜）的组织化学和免疫组织化学。诊断。评估了在分析特殊污渍之前和诊断方面的陷阱和interobserver和Interobserver协议和信心。特殊污渍的使用在肿瘤类型方面增加了手术病理学家之间的完全协议，从63％到74％。置信度得分高的案件比具有低置信度得分的案件具有更高的interobserver协议。这些结果表明，没有神经病理学的专业知识的病理学家在诊断中同意最神经系统肿瘤的诊断，并且在大多数实验室中提供的特殊污渍仅略微增加本协议。

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