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首页> 外文期刊>AJR: American Journal of Roentgenology : Including Diagnostic Radiology, Radiation Oncology, Nuclear Medicine, Ultrasonography and Related Basic Sciences >Kinetic curves of malignant lesions are not consistent across MRI systems: need for improved standardization of breast dynamic contrast-enhanced MRI acquisition.
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Kinetic curves of malignant lesions are not consistent across MRI systems: need for improved standardization of breast dynamic contrast-enhanced MRI acquisition.

机译：在整个MRI系统中，恶性病变的动力学曲线不一致：需要提高乳房动态对比增强MRI采集的标准化水平。

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OBJECTIVE: The purpose of this study was to compare MRI kinetic curve data acquired with three systems in the evaluation of malignant lesions of the breast. MATERIALS AND METHODS: The cases of 601 patients with 682 breast lesions (185 benign, 497 malignant) were selected for review. The malignant lesions were classified as ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC), and other. The dynamic MRI protocol consisted of one unenhanced and three to seven contrast-enhanced images acquired with one of three imaging protocols and systems. An experienced radiologist analyzed the shapes of the kinetic curves according to the BI-RADS lexicon. Several quantitative kinetic parameters were calculated, and the kinetic parameters of malignant lesions were compared across the three systems. RESULTS: Imaging protocol and system 1 were used to image 304 malignant lesions (185 IDC, 62 DCIS); imaging protocol and system 2, 107 lesions (72 IDC, 21 DCIS); and imaging protocol and system 3, 86 lesions (64 IDC, 17 DCIS). Compared with those visualized with imaging protocols and systems 1 and 2, IDC lesions visualized with imaging protocol and system 3 had significantly less initial enhancement, longer time to peak enhancement, and a slower washout rate (p < 0.004). Only 47% of IDC lesions imaged with imaging protocol and system 3 exhibited washout type curves, compared with 75% and 74% of those imaged with imaging protocols and systems 2 and 1, respectively. The diagnostic accuracy of kinetic analysis was lowest for imaging protocol and system 3, but the difference was not statistically significant. CONCLUSION: The kinetic curve data on malignant lesions acquired with one system showed significantly lower initial contrast uptake and a different curve shape in comparison with data acquired with the other two systems. Differences in k-space sampling, T1 weighting, and magnetization transfer effects may be explanations for the difference.
机译：目的：本研究的目的是比较三种系统获得的MRI动力学曲线数据，以评估乳腺恶性病变。材料与方法：选择601例乳腺病灶682例（良性185例，恶性497例）进行回顾性分析。恶性病变分为原位导管癌（DCIS），浸润性导管癌（IDC）等。动态MRI协议由一幅未增强图像和三到七幅对比度增强图像组成，这些图像是通过三种成像协议和系统之一获取的。一位经验丰富的放射学家根据BI-RADS词典分析了动力学曲线的形状。计算了几个定量动力学参数，并比较了三个系统中恶性病变的动力学参数。结果：成像方案和系统1用于对304个恶性病变（185 IDC，62 DCIS）成像;成像方案和系统2，107个病灶（72 IDC，21 DCIS）;成像协议和系统3处，病灶86处（64 IDC，17处DCIS）。与通过成像方案和系统1和2可视化的那些相比，通过成像方案和系统3可视化的IDC病变的初始增强明显更少，达到峰增强的时间更长，并且洗脱速度更慢（p <0.004）。用成像方案和系统3成像的IDC病变中，只有47％表现出冲洗型曲线，而分别使用成像方案和系统2和1成像的IDC病变分别为75％和74％。动力学分析的诊断准确性对于成像方案和系统3最低，但差异无统计学意义。结论：与使用其他两种系统获得的数据相比，使用一种系统获得的恶性病变的动力学曲线数据显示出较低的初始造影剂摄取和不同的曲线形状。 k空间采样，T1权重和磁化传递效应中的差异可能是差异的解释。

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