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首页> 外文期刊>AJR: American Journal of Roentgenology : Including Diagnostic Radiology, Radiation Oncology, Nuclear Medicine, Ultrasonography and Related Basic Sciences >Reproducibility of coronary artery calcified plaque with cardiac 64-MDCT: the Multi-Ethnic Study of Atherosclerosis.
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Reproducibility of coronary artery calcified plaque with cardiac 64-MDCT: the Multi-Ethnic Study of Atherosclerosis.

机译：心脏64-MDCT对冠状动脉钙化斑块的再现性：动脉粥样硬化的多民族研究。

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OBJECTIVE: The Multi-Ethnic Study of Atherosclerosis is a longitudinal study evaluating determinants of future cardiac events and progression of atherosclerosis. Emerging data are showing that coronary artery calcification (CAC) is a robust independent predictor of future cardiac events and that measurement of progression depends on reproducibility of the measure. Reproducibility previously was reported on baseline scans obtained with both electron-beam tomography (EBT) and MDCT. The aim of this study was to compare the interscan variability for both Agatston and volume scores derived with newer (16- and 64-MDCT) scanners with that derived with older scanners in the Multi-Ethnic Study of Atherosclerosis. SUBJECTS AND METHODS: The participants in this study were 4,054 persons who underwent dual scanning with EBT (n = 1,716), 4-MDCT (n = 370), 16-MDCT (n = 1,245), or 64-MDCT (n = 723). Agreement on the presence or absence of CAC was assessed with logistic regression models adjusted for age, sex, body mass index, and scanner type. Among participants with CAC, the log-transformed interscan difference was regressed on log-transformed amount of CAC, age, sex, and body mass index. RESULTS: The percentage agreement for the presence or absence of CAC was high and similar across scanner groups (EBT, 16-MDCT, and 64-MDCT). The greatest adjusted average absolute CAC differences between scans were found with the Aquilion 64 (24%; 95% CI, 20.9-27.6) and LightSpeed Pro 16 (19%; 95% CI, 17.4-21.0) scanners, both differences being significantly greater than with the EBT scanner (16%; 95% CI, 15.4-17.5) (p < 0.05). No differences were found between the EBT, Sensation 16, and Sensation 64 scanners. For volume score, the Aquilion 64 was the only scanner with significantly greater average absolute interscan differences than the EBT scanner (p < 0.001). Volume scoring resulted in lower rescan differences for all scanners. CONCLUSION: For CAC scoring, interscan variability with newer-generation MDCT scanners was similar to but not superior to that with the EBT scanner.
机译：目的：多民族动脉粥样硬化研究是一项纵向研究，旨在评估未来心脏事件和动脉粥样硬化进展的决定因素。新兴数据表明，冠状动脉钙化（CAC）是未来心脏事件的可靠独立预测因子，并且进展的度量取决于该度量的可重复性。以前在通过电子束断层扫描（EBT）和MDCT获得的基线扫描中报告了可重复性。这项研究的目的是在多族裔动脉粥样硬化研究中比较使用新型（16和64-MDCT）扫描仪得出的Agatston和体积分数的扫描间变异性。受试者和方法：本研究的参与者为4,054人，他们接受了EBT（n = 1,716），4-MDCT（n = 370），16-MDCT（n = 1,245）或64-MDCT（n = 723）双重扫描）。通过对年龄，性别，体重指数和扫描仪类型进行调整的逻辑回归模型，评估是否存在CAC。在患有CAC的参与者中，对数转换后的扫描内差异根据CAC的对数转换量，年龄，性别和体重指数回归。结果：在所有扫描仪组（EBT，16-MDCT和64-MDCT）中，存在或不存在CAC的百分比一致性很高。使用Aquilion 64（24％; 95％CI，20.9-27.6）和LightSpeed Pro 16（19％; 95％CI，17.4-21.0）扫描仪发现扫描之间最大的调整后平均绝对CAC差异，两者之间的差异都更大与EBT扫描仪相比（16％; 95％CI，15.4-17.5）（p <0.05）。在EBT，Sensation 16和Sensation 64扫描仪之间没有发现差异。就体积分数而言，Aquilion 64是唯一具有比EBT扫描仪大得多的平均绝对扫描间差的扫描仪（p <0.001）。体积评分可降低所有扫描仪的重新扫描差异。结论：对于CAC评分，新一代MDCT扫描仪的扫描间变异性与EBT扫描仪相似，但并不优于EBT扫描仪。

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