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首页> 外文期刊>Biotechnology Progress >Transport Characteristics of a Novel Local Drug Delivery System Using Nordihydroguaiaretic Acid (NDGA)-Polymerized Collagen Fibers
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Transport Characteristics of a Novel Local Drug Delivery System Using Nordihydroguaiaretic Acid (NDGA)-Polymerized Collagen Fibers

机译：新型使用去氢愈创木酸（NDGA）聚合胶原纤维的新型局部药物输送系统的传输特性

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摘要

The use of nordihydroguaiaretic acid (NDGA)-polymerized collagen fibers as a novel local drug delivery system is introduced.The drag loading of these biocompatible fibers is illustrated with the anti-inflammatory agents dexamethasone and dexamethasone 21-phosphate.Capillary zone electrophoresis was used to measure the amount of drug released from the fibers into phosphate buffered saline with time.From these measurements and the use of a mathematical model,we were able to determine the diffusion coefficients for dexamethasone (D=1.86 x 10~(-14) m~2/s) and dexamethasone 21-phosphate (D=2.36 x 10~(-13) m~2/s) in the NDGA collagen fibers.These values have not been previously reported.These fibers can be used to load other agents as well.The diffusion coefficient of any agent loaded in these fibers can be determined using the techniques and mathematical method described.The rate of drug release from the fibers can be controlled using a PLGA coating.The overall importance of this paper is the potential broad application of this novel drug delivery system for the treatment of various human diseases.
机译：介绍了使用去甲二氢愈创木酚酸（NDGA）聚合的胶原纤维作为新型局部药物递送系统，并用抗炎药地塞米松和地塞米松21-磷酸酯说明了这些生物相容性纤维的阻力负载，并使用毛细管区带电泳测量随时间从纤维释放到磷酸盐缓冲盐水中的药物量。通过这些测量和数学模型的使用，我们能够确定地塞米松的扩散系数（D = 1.86 x 10〜（-14）m〜 2 / s）和NDGA胶原纤维中的21-磷酸地塞米松（D = 2.36 x 10〜（-13）m〜2 / s），这些值以前没有被报道过，这些纤维可用于装载其他试剂，例如可以使用上述技术和数学方法确定在这些纤维中负载的任何药物的扩散系数。可以使用PLGA涂层控制药物从纤维中释放的速率。这种新颖的药物递送系统在治疗各种人类疾病中具有潜在的广泛应用。

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