DATE Analysis: A General Theory of Biological Change Applied to Microarray Data

David Rasnick

首页> 外文期刊>Biotechnology Progress >DATE Analysis: A General Theory of Biological Change Applied to Microarray Data

【24h】

DATE Analysis: A General Theory of Biological Change Applied to Microarray Data

机译：日期分析：生物变化的通用理论应用于微阵列数据

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

In contrast to conventional data mining, which searches for specific subsets of genes (extensive variables) to correlate with specific phenotypes, DATE analysis correlates intensive state variables calculated from the same datasets. At the heart of DATE analysis are two biological equations of state not dependent on genetic pathways. This result distinguishes DATE analysis from other bioinformatics approaches. The dimensionless state variable F quantifies the relative overall cellular activity of test cells compared to well-chosen reference cells. The variable π_i is the fold-change in the expression of the ith gene of test cells relative to reference. It is the fraction φ of the genome undergoing differential expression-not the magnitude n-that controls biological change. The state variable φ is equivalent to the control strength of metabolic control analysis. For tractability, DATE analysis assumes a linear system of enzyme-connected networks and exploits the small average contribution of each cellular component. This approach was validated by reproducible values of the state variables F, RNA index, and φ calculated from random subsets of transcript micro-array data. Using published microarray data, F, RNA index, and φ were correlated with: (1) the blood-feeding cycle of the malaria parasite, (2) embryonic development of the fruit fly, (3) temperature adaptation of Killifish, (4) exponential growth of cultured S. pneumoniae, and (5) human cancers. DATE analysis was applied to aCGH data from the great apes. A good example of the power of DATE analysis is its application to genomically unstable cancers, which have been refractory to data mining strategies.

机译：与传统的数据挖掘相反，传统的数据挖掘通过搜索特定的基因子集（广泛的变量）来与特定的表型相关联，而DATE分析则将根据相同数据集计算出的密集状态变量进行关联。 DATE分析的核心是两个不依赖遗传途径的生物学状态方程。该结果将DATE分析与其他生物信息学方法区分开来。与选择好的参考细胞相比，无量纲状态变量F量化了测试细胞的相对总体细胞活性。变量π_i是测试细胞的第i个基因相对于参考的表达的倍数变化。控制差异的是基因组经历差异表达的分数φ而非大小n。状态变量等于代谢控制分析的控制强度。为了便于处理，DATE分析假设酶连接网络为线性系统，并利用每个细胞成分的较小平均贡献。通过从转录本微阵列数据的随机子集计算出的状态变量F，RNA指数和φ的可复制值，验证了该方法。使用公开的微阵列数据，F，RNA指数和φ与以下各项相关：（1）疟原虫的血液喂养周期;（2）果蝇的胚胎发育;（3）of鱼的温度适应性;（4）培养的肺炎链球菌的指数增长，以及（5）人类癌症。 DATE分析应用于大猿的aCGH数据。 DATE分析的强大功能的一个很好的例子是它在基因组不稳定的癌症中的应用，这种癌症对于数据挖掘策略是难以接受的。

著录项

来源
《Biotechnology Progress》 |2009年第5期|共14页
作者
David Rasnick;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类生物科学;
关键词
metabolic; bioinformatics; state equations; control-analysis; data mining;

机译：代谢;生物信息学;状态方程;控制分析;数据挖掘;

相似文献

外文文献
中文文献
专利

1. DATE Analysis: A General Theory of Biological Change Applied to Microarray Data [J] . David Rasnick Biotechnology Progress . 2009,第5期

机译：日期分析：生物变化的通用理论应用于微阵列数据
2. INTEGRATED STATISTICAL ANALYSIS OF cDNA MICROARRAY AND NIR SPECTROSCOPIC DATA APPLIED TO A HEMP DATASET [J] . T. H. Reijmers, C. Maliepaard, H. C. Van Den Broeck, Journal of Bioinformatics and Computational Biology . 2005,第4期

机译：CDNA微阵列和NIR光谱数据的集成统计分析应用于HEMP数据集
3. The microarray data analysis process: From raw data to biological significance [J] . N. Eric Olson Neurotherapeutics . 2006,第3期

机译：微阵列数据分析过程：从原始数据到生物学意义
4. Adaptive Threshold to Detect Biologically Meaningful Changes in Microarray Data [C] . Yutaka Fukuoka, Hidenori Inaoka, Makoto Noshiro Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2008

机译：自适应阈值检测微阵列数据的生物学有意义的变化
5. Systems biology approaches for analysis of microarray data and their applications in biological discovery. [D] . Ergun, Ayla. 2010

机译：用于分析微阵列数据的系统生物学方法及其在生物学发现中的应用。
6. Bioinformatics Techniques in Microarray Research: Applied Microarray Data Analysis Using R and SAS Software [O] . Ryan T. Demmer, Paul Pavlidis, Panos N. Papapanou -1

机译：微阵列研究中的生物信息学技术：使用R和SAS软件应用微阵列数据分析
7. Decision-making is the process of analyzing information about a problem situation and comparing it to a specific conclusion in order to solve a specific problematic (Yıkılmaz, 2001; Miller and Byrnes, 2001). Decision-making styles are a mechanism that is influenced by the internal and external conditions that determine the direction of the decisions of the individual, the content of the decision-making process, and the outcome of the decision-making process (Payne, Bettman and Johson, 1993; Bavol’ár and Orosová, 2015). ACT is a contemporary member of the Cognitive Behavioral Therapy family. ACT (Acceptance and commitment therapy) has both similar and different directions with Behavioral Therapies and Cognitive Therapies (Herbet and Forman, 2011; Hayes, 2004). KKT responds to classical behavioral treatments using both existential and cognitive approaches in the analysis of behavior. KKT is a science wing that tries to solve human problems with a wider perspective aimed at solving problematic human behaviors (Plumb, Stewart, Dahl and Lundgren, 2009). It is seen that there is very little research about the new approach of ACT approach when the aiming country of our country is screened and it is thought that our country will contribute to the field of psychological counseling with the work done. In the scope of the research, experimental and control groups and preliminary test, post-test and follow-up measurements of 2x3 experimental design were used. The study's study group consists of a total of 24 (12 experimental and 12 control groups) university students studying in different departments and levels, continuing their education in the academic year of 2015-2016 in Ağrı province and İbrahim Chechen University in 2015-2016 academic year. The average age of participants in the experiment and control group is 20. There were 12 participants in the experimental group, 7 female and 5 male, and 12 participants, 7 female and 5 male in the control group. Personal Information Form and Decision Making Style Scale prepared by the researcher were used in the research. In order to decide on the tests to be used in the course of analyzing the data, the scores of the participant's Decision Styles Scale pre-test, which are placed primarily in the experimental and control groups, it was analyzed whether the basic expectations of parametric tests were answered. As a result of the analysis made, the scores, skewness and kurtosis coefficients obtained from the Decision Making Styles Scale were given to the experimental and control groups. It was determined that the distribution was normal in the result of Shapiro-Wilk test, in which the skewness and kurtosis coefficients of each sub-scale were ranked between -1 and +1. Participants in the experimental and control groups; homogeneity test results for decision-style pre-test measurements indicate that the data are homogeneous. According to the results of the Mauchly Globalness Test, it has been determined that working supports the hypothesis. It was determined that there was no significant difference between the pre-test scores obtained from dependent decision-making style of experiment and control groups, but the test group showed lower mean scores at the significant level within the scores of post-test and follow-up tests. Therefore, it can be said that the ACT-oriented psychoeducation program applied to the experimental group reduces the dependent decision-making style scores from the decision style sub-dimensions and the psychoeducation program has a lasting effect. It was determined that there was no significant difference between pre-test, post-test and follow-up scores obtained from the Spontaneous-Instant Decision Style of experiment and control groups. Thus, it can be said that this situation does not cause a significant difference in the Spontaneous-Decision-Making Style scores from the decision style sub-dimensions of the ACT-oriented psychoeducation program applied to the experimental group. The ACT -oriented psychoeducation program had a decline in the intuitive decision-making styles of the individuals, but this decrease did not create significant differences. Thus, it can be said that this situation does not make a meaningful difference in the intuitive decision style scores from the decision style sub-dimensions of the KKT oriented psychoeducation program applied to the experimental group. The pre-test scores obtained from the rational decision-making style of the experimental and control groups showed that there was a difference between the post-test and the follow-up scores, but this difference was not significant. As a result of the analysis, it was determined that the test group had higher levels of rational decision style than the pre - test scores in the post test and follow - up scores, whereas the post test and follow - up test scores in the control group rational decision style showed a decrease compared to the pre - test scores. the pre - test scores. Decision-making Styles Scale Avoidant Decision Making As a result of the analysis of the mean scores of the subscale scores of pre-test, post-test and follow-up measures, the group effect was found to be insignificant. It was determined that the experimental and control groups differed significantly from the pre-test scores obtained from the avoidant decision-making style but did not show any significant change within the scores of the post-test and follow-up tests. [O] . mustafa ercengiz, ali haydar şar 2018

机译：决策是分析有关问题情况的信息并将其与特定结论进行比较的过程，以解决特定的问题（Yıkılmaz，2001; Miller和Byrnes，2001）。决策风格是一种机制，受到内部和外部条件的影响，确定个人决定的方向，决策过程的内容以及决策过程的结果（PAYNE，BETTMAN和BEDNE） Johson，1993;Bavol'ár和奥萨洛瓦，2015）。法案是认知行为治疗家庭的当代成员。行为（验收和承诺治疗）具有与行为疗法和认知疗法的类似和不同方向（Herbet和Forman，2011; Hayes，2004）。 KKT在分析行为中使用存在性和认知方法来响应古典行为治疗方法。 KKT是一个科学翼，试图解决人类问题，旨在解决有问题的人类行为（铅垂，斯图尔特，Dahl和Lundgren，2009）。有人认为，当我们国家的瞄准国家进行筛选时，有关行动方法的新方法几乎没有研究，并且认为我们的国家将为完成工作做出贡献的心理咨询领域。在研究的范围内，使用实验和对照组和初步测试，使用后测试和后续测量的2x3实验设计。该研究的研究小组包括共24名（12个实验和12个对照组）大学学生在不同的部门和水平上学习，在2015-2016学术上继续进行2015-2016的学术年度2015-2016学年年。实验和对照组参与者的平均年龄是20.实验组中有12名参与者，7名女性和5名男性，12名参与者，7名女性和5名男性。研究人员准备的个人信息表格和决策制定风格规模在研究中使用。为了决定在分析数据的过程中使用的测试，参与者的决策风格刻度预测的分数主要在实验和对照组中进行，分析了参数的基本期望吗？测试得到了回答。由于对实验和对照组给出了从决策曲调标度获得的分数，偏移和峰度分子系数。确定该分布是正常的在成熟的-WILK试验结果中，其中每亚级的偏差和刚度系数在-1到+1之间排名。实验和对照组的参与者;决策式预测测量的同质性测试结果表明数据是均匀的。根据毛毛环保试验的结果，已确定工作支持假设。据确定，从依赖决策风格的实验和对照组获得的预测分数之间没有显着差异，但测试组在测试后的分数内显示出较低的平均分数和后续的分数 - 测试。因此，可以说，应用于实验组的面向活动的心理教育程序减少了决策风格子维度的依赖决策风格分数，并且心理教育程序具有持久的效果。据确定，从实验和对照组自发决策风格获得的预测试，测试后和后续评分之间没有显着差异。因此，可以说这种情况不会导致从应用于实验组的活动导向的心理教育程序的决策风格分数的自发决策风格分数显着差异。行为的心理教育计划在个人直观的决策风格下降，但这种减少并没有产生显着的差异。因此，可以说，这种情况不会在从应用于实验组的KKT导向的心理教育程序的决策风格分数中产生有意义的决策风格分数。从实验和对照组的理性决策风格获得的预测分数显示后检验后和随访评分之间存在差异，但这种差异并不重要。由于分析，确定测试组的理性决策风格较高，而不是后测试和后续分数的预测分数，而对照组合理决策风格的后测试和后续测试分数显示出与预测试分数相比的减少。预测分数。决策款式扩展避免决策由于分析了预测试，测试后和后续措施的班次评分的平均分数，发现群体效应是微不足道的。确定实验和对照组从避免决策风格获得的预测评分中显着不同，但在测试后和后续测试的分数内没有显示出任何重大变化。

DATE Analysis: A General Theory of Biological Change Applied to Microarray Data

摘要

著录项

相似文献

相关主题

期刊订阅