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首页> 外文期刊>The Natural Products Journal >Preclinical Study to Evaluate the Effect of Polyherbal Formulation on Metformin: Potential Herb-drug Interaction
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Preclinical Study to Evaluate the Effect of Polyherbal Formulation on Metformin: Potential Herb-drug Interaction

机译：临床前研究评价聚丙烯聚丙烯聚丙烯的效果：潜在的草药互动

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Objective: The aim of the present study was to examine the effect of a polyherbal formulation(PHF) on pharmacokinetics and pharmacodynamics of metformin in rats.Methods: The present study was conducted to determine the beneficial outcomes of PHF along withmetformin by studying herb-drug interactions. PHF was prepared by five indigenous herbs, Thoseare being used traditionally as antidiabetic in India. PHF doses (100 mg/kg/day) were administeredto Sprague-Dawley rats by an oral route of different groups for multiple weeks except for control.Metformin (100 mg/kg) was orally administered at 7th and 30th day to control and PHF pretreatedrats for pharmacokinetics study while pharmacodynamics study was conducted in PHF treated anduntreated diabetic rats. No more significant difference was found in the pharmacokinetic parametersin PHF treated at 7th day while a significant increase was found in AUC at the 30th day.Results: The hypoglycemic effect was observed with a combination of metformin and PHF, significantlymore compared to control. Metformin decreased the blood glucose 1.51 fold at 7th day and 1.7fold at 30th day respectively, compared to control.Conclusion: Thus, this finding indicates that PHF increased the AUC of metformin. It might increasebioavailability through drug-herb interaction thereby affecting the therapeutic effect. Thisformulation can be considered as an adjunct to metformin in the management of diabetes mellitus.
机译：目的：目前研究的目的是研究聚丙烯制剂（PHF）对大鼠二甲双胍的药代动力学和药效学的影响。方法：通过研究草药来确定本研究以确定PHF的有益结果吗？互动。 PHF由五个土着草药制备，传统上用于印度的抗糖尿病。除了对照，除了对照，在7号和第30天口服给药，将在不同群体的口腔途径进行Sprague-Dawley大鼠Sprague-Dawley大鼠施用Sprague-Dawley大鼠。对于药代动力学研究，而药物动力学研究在PHF治疗的Anduntreated糖尿病大鼠中进行。在第7天治疗的药代动力学参数中没有更大的差异，而在第30天在AUC中发现显着增加。结果：与对照相比，用二甲双胍和PHF的组合观察到降血糖效果，与对照相比，较高。与对照相比，二甲双胍分别在第7天减少了血糖1.51倍，并分别在第30天折叠1.7倍。因此，该发现表明PHF增加了二甲双胍的AUC。它可能通过药草的相互作用来增加，从而影响治疗效果。在糖尿病的管理中，可以将这种情况视为二甲双胍的辅助。

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