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首页> 外文期刊>Phytotherapy research: PTR >Effect and mechanism of verbascoside on hypoxic memory injury in plateau
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Effect and mechanism of verbascoside on hypoxic memory injury in plateau

机译：牙唇岩对高原缺氧记忆损伤的影响及机制

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摘要

Verbascoside is a water-soluble natural phenylethanoid glycoside and distributes widely in plants. It has been proved with antioxidant, neuroprotective, anti-inflammatory, antibacterial, and immunomodulatory bioactivities. In this experiment, the effect and mechanism of verbascoside on hypoxic memory injury were studied in a low-pressure and low-oxygen chamber. Verbascoside (50, 150, and 300 mg/kg) was intragastrically administered once a day for 7 days. On the fourth day, rats were placed in the chamber to simulate a 7,500 m high-altitude environment The eight-arm maze was used to test the memory ability. The levels of MDA, GSH, and T-SOD in plasma, brain-NH, and hippocampus were detected. The mRNA expression of mTOR, P70S6K, and 4E-BP1 in the hippocampus tissue was determined by PCR. The protein expression of P-mTOR, P-P70S6K, P-4E-BP1, and Cleaved Caspase-3 in the hippocampus tissue was determined by western blot. The results indicated that administration with verbascoside could obviously reduce the working memory error, reference memory error, total errors, and total time; relieve the neuron damage in CA(1) region of the hippocampus; and decrease the oxidative stress correlation enzyme activity in plasma, brain, and hippocampus. The amelioration of verbascoside on high altitude-induced memory impairment may be associated with the adjustment of oxidative stress and mTOR signaling pathway.
机译：术术是一种水溶性天然苯乙烯替糖苷，并在植物中广泛分布。已证明抗氧化剂，神经保护，抗炎，抗菌和免疫调节性生物活性。在该实验中，在低压和低氧气室中研究了血管内酯对缺氧记忆损伤的影响和机制。血管内酯（50,150和300mg / kg）每天一次胃内给药7天。在第四天，大鼠置于腔室中以模拟7,500米的高空环境，八臂迷宫用于测试内存能力。检测MDA，GSH和T-SOD的水平检测到血浆，脑 - NH和海马中的水平。通过PCR测定海马组织中MTOR，P70S6K和4E-BP1的mRNA表达。通过蛋白质印迹测定p-mTOR，p-P70s6k，p-4e-bp1和海马组织中裂解的caspase-3的蛋白质表达。结果表明，用术语给药可以显然可以减少工作记忆误差，参考记忆误差，总误差和总时间;缓解海马CA（1）区的神经元损伤;并降低血浆，脑和海马中的氧化应激相关酶活性。血管内诱导的内存损伤对术的改善可能与氧化应激和MTOR信号传导途径的调节相关。

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  • 来源
    《Phytotherapy research: PTR》 |2019年第10期|共10页
  • 作者

    Li Maoxing; Zhu Yuting; Li Jing; Chen Liping; Tao Wendi; Li Xiaoling; Qiu Yan;

  • 作者单位

    940th Hosp Joint Logist Support Force Dept Pharm PLA 333 South Binghe Rd Lanzhou 730050 Gansu Peoples R China;

    940th Hosp Joint Logist Support Force Dept Pharm PLA 333 South Binghe Rd Lanzhou 730050 Gansu Peoples R China;

    940th Hosp Joint Logist Support Force Dept Pharm PLA 333 South Binghe Rd Lanzhou 730050 Gansu Peoples R China;

    940th Hosp Joint Logist Support Force Dept Pharm PLA 333 South Binghe Rd Lanzhou 730050 Gansu Peoples R China;

    940th Hosp Joint Logist Support Force Dept Pharm PLA 333 South Binghe Rd Lanzhou 730050 Gansu Peoples R China;

    940th Hosp Joint Logist Support Force Dept Pharm PLA 333 South Binghe Rd Lanzhou 730050 Gansu Peoples R China;

    Shanghai Univ Med &

    Hlth Sci Pudong Hosp Dept Pharm Shanghai Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 中草药治疗学（八法论治）;
  • 关键词

    apoptosis; eight-arm maze; hypoxia memory impairment; mTOR signaling pathway; oxidative stress; verbascoside;

    机译：细胞凋亡;八臂迷宫;缺氧记忆障碍;MTOR信号传导途径;氧化应激;血管内酯;

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