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首页> 外文期刊>Herz >PON1 L55M and Q192R gene polymorphisms and CAD risks in patients with hyperlipidemia: Clinical study of possible associations
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PON1 L55M and Q192R gene polymorphisms and CAD risks in patients with hyperlipidemia: Clinical study of possible associations

机译：PON1 L55M和Q192R基因多态性和高脂血症患者的CAD风险：可能的关联临床研究

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ObjectiveA decreased plasma high density lipoprotein (HDL) cholesterol level is a strong risk factor for coronary artery disease (CAD). Antioxidant activity of HDL mainly lies in the activity of paraoxonase (PON). This study aimed to investigate the relationships between PON1 L55M and Q192R polymorphisms, and the risks of CAD in patients with hyperlipidemia.MethodsFrom January 2014 to January 2016, 244 patients were divided into hyperlipidemia, hyperlipidemia+ CAD, and control groups. The hyperlipidemia and hyperlipidemia+ CAD groups were designated as the case group. Serum PON1 concentrations were measured using the enzyme-linked immunosorbent assay. After isolating genomic DNA, the PON1 L55M and Q192R genes were amplified by polymerase chain reaction and sequenced.ResultsIn the case group, the genotypes LM and LL were detected significantly more often than in the control group, as were the alleles R (33.33%, 42.12%) and L (22.78%, 29.11%). The frequency of QR and RR genotypes was significantly higher in the hyperlipidemia+ CAD group than in the hyperlipidemia group; the allele R in the hyperlipidemia+ CAD group (42.77%) was more frequent than in the hyperlipidemia group (23.78%). The Q192R polymorphism was associated with low serum PON1 concentrations, and the lowest concentration was observed in the 192QR+ 192RR genotype (P= 0.03). Logistic regression analysis showed asignificant correlation between the 192R allele and smoking (P= 0.03), body mass index (P= 0.02), systolic blood pressure (P= 0.004), total cholesterol (P= 0.03), triglycerides (P= 0.01), HDL (P= 0.004), and low density lipoprotein (P= 0.02).ConclusionThe PON1 alleles 192R and 55L are associated with CAD, and the Q192R polymorphism may be arisk factor for CAD.
机译：特调物降低血浆高密度脂蛋白（HDL）胆固醇水平是冠状动脉疾病（CAD）的强风险因素。 HDL的抗氧化活性主要位于约束酶（PON）的活性。本研究旨在调查PON1 L55M和Q192R多态性之间的关系，高脂血症患者的CAD风险。从2014年1月至2016年1月，244名患者分为高脂血症，高脂血症+ CAD和对照组。特异性血症和高脂血症+ CAD组被指定为案例组。使用酶联免疫吸附测定测量血清PON1浓度。在分离基因组DNA后，通过聚合酶链反应扩增PON1 L55M和Q192R基因并测序。案例组，比对照组显着检测到基因型LM和LL，如等位基因R（33.33％， 42.12％）和L（22.78％，29.11％）。高脂血症+ CAD组QR和RR基因型的频率显着高于高脂血症组;高脂血症+ CAD组（42.77％）的等位基因R比高脂血症组更频繁（23.78％）。 Q192R多态性与低血清PON1浓度相关，在192QR + 192RR基因型中观察到最低浓度（P = 0.03）。 Logistic回归分析显示192R等位基因和吸烟（P = 0.03），体质量指数（P = 0.02），收缩压（P = 0.004），总胆固醇（P = 0.03），甘油三酯（P = 0.01）之间的相似性，HDL（P = 0.004）和低密度脂蛋白（P = 0.02）。结论PON1等位基因192R和55L与CAD相关，并且Q192R多态性可以是CAD的运动因子。

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