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Significant association between paraoxonase 1 rs662 polymorphism and coronary heart disease A meta-analysis in the Chinese population

机译：律酶1 rs662多态性与冠心病之间的重要关联在中国人口中的荟萃分析

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Background A growing number of studies have suggested that the single nucleotide polymorphism (SNP) rs662 (G>A) in paraoxonase 1 (PON1) is significantly associated with susceptibility to coronary heart disease (CHD) in the Chinese population. To further evaluate the effects of thePON1RS662 (G>A) polymorphism on the risk of CHD, we performed a meta-analysis in a Chinese population. Methods PubMed, Embase, Wanfang Data, Chinese National Knowledge Infrastructure (CNKI) were searched to identify eligible studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the associations between RS662 (G>A) and CHD. Result In the meta-analysis, we identified 14 articles, including a total of 4835 CHD patients and 5111 controls in the Chinese population. Our result showed that overall rs662 (G>A) was significantly associated with susceptibility to CHD in the Chinese population when compared with healthy controls. Furthermore, a G allele suggested an elevated risk of CHD. In the subgroup analyses stratified by ethnicity and geographic areas, significant associations were found in Chinese Han and South China, but not in North China. Conclusion The present meta-analysis suggests that rs662 (G>A) SNP in PON1 is associated with CHD risk; the G allele might be the risk allele for CHD susceptibility in the Chinese population. However, more research is required to make a definite conclusion.
机译：背景技术越来越多的研究表明，律酶1（PON1）中的单个核苷酸多态性（SNP）RS662（G> A）与中国人群中冠心病（CHD）的易感性显着相关。为了进一步评估PON1RS662（G> A）多态性对CHD风险的影响，我们在中国人群中进行了荟萃分析。方法采用PubMed，Embase，Wanfang数据，中国国家知识基础设施（CNKI）被搜查识别合格的研究。汇集的赔率比（ORS）和95％置信区间（CIS）用于评估RS662（G> A）和CHD之间的关联强度。结果在荟萃分析中，我们确定了14篇文章，其中共有4835名CHD患者和5111例在中国人口控制。我们的结果表明，与健康对照相比，总共RS662（G> A）与中国人群的敏感性显着相关。此外，G等位基因表明CHD的升高风险。在民族和地理区域分类的亚组分析中，中国汉汉和华南的重大协会，但不是在华北。结论本元分析表明PON1中的RS662（G> A）SNP与CHD风险有关; G等位基因可能是中国人口中CHD易感性的风险等位基因。但是，需要更多的研究来做出明确的结论。

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